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Incidence of selective serotonin reuptake inhibitor (SSRI) induced hyponatraemia due to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion in the elderly

International journal of geriatric psychiatry, 1998-01, Vol.13 (1), p.12-15 [Peer Reviewed Journal]

Copyright © 1998 John Wiley & Sons, Ltd. ;1998 INIST-CNRS ;ISSN: 0885-6230 ;EISSN: 1099-1166 ;DOI: 10.1002/(SICI)1099-1166(199801)13:1<12::AID-GPS718>3.0.CO;2-F ;PMID: 9489575

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Title:
Incidence of selective serotonin reuptake inhibitor (SSRI) induced hyponatraemia due to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion in the elderly
Author: Bouman, Walter P. ; Pinner, Gillian ; Johnson, Hazel
Subjects: Acute Disease ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Dementia - diagnosis ; Dementia - drug therapy ; Dementia - psychology ; Depressive Disorder - diagnosis ; Depressive Disorder - drug therapy ; Depressive Disorder - psychology ; Drug toxicity and drugs side effects treatment ; elderly ; Female ; Humans ; hyponatraemia ; Hyponatremia - epidemiology ; Hyponatremia - etiology ; Inappropriate ADH Syndrome - chemically induced ; Inappropriate ADH Syndrome - complications ; Inappropriate ADH Syndrome - diagnosis ; Incidence ; Male ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. Drug treatments ; Retrospective Studies ; Serotonin Uptake Inhibitors - adverse effects ; Serotonin Uptake Inhibitors - therapeutic use ; Severity of Illness Index ; SIADH ; Sodium - blood ; SSRIs
Is Part Of: International journal of geriatric psychiatry, 1998-01, Vol.13 (1), p.12-15
Description: Objective. The study determines the incidence of SSRI‐induced hyponatraemia due to SIADH in an elderly psychiatric inpatient population. Design. A retrospective case‐note study. Setting. An acute old age psychiatry ward. Sample. Patients admitted from January 1 to December 31, 1996. Measures. Demographics, medication, psychiatric diagnoses, plasma sodium level and physical comorbidity were collected. Patients on SSRIs were selected and those developing hyponatraemia due to SIADH were identified. Results. Of 32 patients taking SSRIs, four developed symptomatic hyponatraemia due to SIADH (12.5%). A further four developed asymptomatic hyponatraemia following introduction of an SSRI (12.5%), although laboratory confirmation of SIADH was lacking. Conclusions. The incidence of SSRI‐induced hyponatraemia due to SIADH has not previously been established. This study shows a high incidence in elderly patients of this potentially dangerous complication. Clinical practice in the prescription of SSRIs to elderly people must change to include monitoring of electrolytes for early detection and reduction of morbidity. © 1998 John Wiley & Sons, Ltd.
Publisher: Chichester, UK: John Wiley & Sons, Ltd
Language: English
Identifier: ISSN: 0885-6230
EISSN: 1099-1166
DOI: 10.1002/(SICI)1099-1166(199801)13:1<12::AID-GPS718>3.0.CO;2-F
PMID: 9489575
Source: MEDLINE
Alma/SFX Local Collection

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Incidence of selective serotonin reuptake inhibitor (SSRI) induced hyponatraemia due to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion in the elderly

Copyright © 1998 John Wiley & Sons, Ltd. ;1998 INIST-CNRS ;ISSN: 0885-6230 ;EISSN: 1099-1166 ;DOI: 10.1002/(SICI)1099-1166(199801)13:1<12::AID-GPS718>3.0.CO;2-F ;PMID: 9489575

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