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Strong influence of human leukocyte antigen-DP variants on response to hepatitis B vaccine in a Japanese population

Vaccine, 2017-10, Vol.35 (42), p.5662-5665 [Peer Reviewed Journal]

2017 Elsevier Ltd ;Copyright © 2017 Elsevier Ltd. All rights reserved. ;Copyright Elsevier Limited Oct 9, 2017 ;ISSN: 0264-410X ;EISSN: 1873-2518 ;DOI: 10.1016/j.vaccine.2017.08.045 ;PMID: 28882445

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Title:
Strong influence of human leukocyte antigen-DP variants on response to hepatitis B vaccine in a Japanese population
Author: Okada, Yuya ; Uno, Naoki ; Sato, Shuntaro ; Mori, Sayaka ; Sasaki, Daisuke ; Kaku, Norihito ; Kosai, Kosuke ; Morinaga, Yoshitomo ; Hasegawa, Hiroo ; Yanagihara, Katsunori
Subjects: Adult ; Alleles ; Antigenic determinants ; Antigens ; Asian Continental Ancestry Group - genetics ; Case-Control Studies ; Chronic infection ; Deoxyribonucleic acid ; DNA ; DNA polymerase ; Female ; Genome-wide association studies ; Genome-Wide Association Study - methods ; Genomes ; Genotype ; Health risks ; Hepatitis ; Hepatitis B ; Hepatitis B Antibodies - immunology ; Hepatitis B surface antibody ; Hepatitis B vaccine ; Hepatitis B Vaccines - immunology ; Hepatitis B virus - immunology ; Hepatitis B, Chronic - immunology ; Hepatology ; HLA-DP Antigens - genetics ; HLA-DP Antigens - immunology ; HLA-DQ Antigens - genetics ; HLA-DQ Antigens - immunology ; Human leukocyte antigen ; Humans ; Immune clearance ; Immune response ; Immune system ; Infections ; Interferon ; Laboratories ; Leukocytes ; Liver cancer ; Male ; Medical students ; Polymorphism, Single Nucleotide - genetics ; Polymorphism, Single Nucleotide - immunology ; Population ; Population studies ; Regression analysis ; Single nucleotide polymorphism ; Students ; Vaccination ; Vaccines ; Viruses ; Young Adult
Is Part Of: Vaccine, 2017-10, Vol.35 (42), p.5662-5665
Description: •The association of HLA variants with response to hepatitis B vaccination was tested.•HLA-DP variants were strongly associated with response to hepatitis B vaccination.•HLA-DQ variants were not associated with response to hepatitis B vaccination. Genome-wide association studies (GWASs) have reported that human leukocyte antigen (HLA) variants are associated with chronic hepatitis B, spontaneous hepatitis B virus (HBV) clearance, and response to hepatitis B vaccine. Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance. However, the data on the SNPs associated with response to hepatitis B vaccine are inconclusive. The objective of this study was to determine whether these four HLA SNPs that have been identified as risk loci for chronic HBV infection are associated with response to hepatitis B vaccine in a Japanese population. We enrolled 278 medical students who received hepatitis B vaccination and measured anti-hepatitis B surface (HBs) antibody titers 1month after a three-dose vaccination series. We found that rs9277535 and rs3077 in HLA-DP were strongly associated with response to hepatitis B vaccine (odds ratio [OR]=0.31 and 0.32, P=0.004 and 0.010, respectively). These two SNPs were significantly associated with anti-HBs titers in an allele-dependent manner. On the other hand, rs2856718 and rs7453920 in HLA-DQ were not associated with response to hepatitis B vaccine. These results indicate that rs9277535 and rs3077 in HLA-DP are the major determinants of response to hepatitis B vaccine, whereas rs2856718 and rs7453920 in HLA-DQ have little effect on the immune response to hepatitis B vaccine.
Publisher: Netherlands: Elsevier Ltd
Language: English
Identifier: ISSN: 0264-410X
EISSN: 1873-2518
DOI: 10.1016/j.vaccine.2017.08.045
PMID: 28882445
Source: MEDLINE
ProQuest Central

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Strong influence of human leukocyte antigen-DP variants on response to hepatitis B vaccine in a Japanese population

2017 Elsevier Ltd ;Copyright © 2017 Elsevier Ltd. All rights reserved. ;Copyright Elsevier Limited Oct 9, 2017 ;ISSN: 0264-410X ;EISSN: 1873-2518 ;DOI: 10.1016/j.vaccine.2017.08.045 ;PMID: 28882445

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