Language:

Immunodeficiency at the start of combination antiretroviral therapy in low-, middle-, and high-income countries

Journal of acquired immune deficiency syndromes (1999), 2014-01, Vol.65 (1), p.e8-e16 [Peer Reviewed Journal]

Copyright Lippincott Williams & Wilkins Jan 1, 2014 ;ISSN: 1525-4135 ;EISSN: 1944-7884 ;DOI: 10.1097/qai.0b013e3182a39979 ;PMID: 24419071 ;CODEN: JDSRET

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Immunodeficiency at the start of combination antiretroviral therapy in low-, middle-, and high-income countries
Author: Avila, Dorita ; Althoff, Keri N ; Mugglin, Catrina ; Wools-Kaloustian, Kara ; Koller, Manuel ; Dabis, François ; Nash, Denis ; Gsponer, Thomas ; Sungkanuparph, Somnuek ; McGowan, Catherine ; May, Margaret ; Cooper, David ; Chimbetete, Cleophas ; Wolff, Marcelo ; Collier, Ann ; McManus, Hamish ; Davies, Mary-Ann ; Costagliola, Dominique ; Crabtree-Ramirez, Brenda ; Chaiwarith, Romanee ; Cescon, Angela ; Cornell, Morna ; Diero, Lameck ; Phanuphak, Praphan ; Sawadogo, Adrien ; Ehmer, Jochen ; Eholie, Serge P ; Li, Patrick C K ; Fox, Matthew P ; Gandhi, Neel R ; González, Elsa ; Lee, Christopher K C ; Hoffmann, Christopher J ; Kambugu, Andrew ; Keiser, Olivia ; Ditangco, Rossana ; Prozesky, Hans ; Lampe, Fiona ; Kumarasamy, Nagalingeswaran ; Kitahata, Mari ; Lugina, Emmanuel ; Lyamuya, Rita ; Vonthanak, Saphonn ; Fink, Valeria ; d'Arminio Monforte, Antonella ; Luz, Paula Mendes ; Chen, Yi-Ming A ; Minga, Albert ; Casabona, Jordi ; Mwango, Albert ; Choi, Jun Y ; Newell, Marie-Louise ; Bukusi, Elizabeth A ; Ngonyani, Kapella ; Merati, Tuti P ; Otieno, Juliana ; Bosco, Mwebesa B ; Phiri, Sam ; Ng, Oon T ; Anastos, Kathryn ; Rockstroh, Jürgen ; Santos, Ignacio ; Oka, Shinichi ; Somi, Geoffrey ; Stephan, Christoph ; Teira, Ramon ; Wabwire, Deo ; Wandeler, Gilles ; Boulle, Andrew ; Reiss, Peter ; Wood, Robin ; Chi, Benjamin H ; Williams, Carolyn ; Sterne, Jonathan A ; Egger, Matthias
Subjects: Adolescent ; Adult ; Age Factors ; Anti-HIV Agents - therapeutic use ; Antiretroviral drugs ; CD4 Lymphocyte Count - statistics & numerical data ; Developed Countries - statistics & numerical data ; Developing Countries - statistics & numerical data ; Drug therapy ; Female ; Glycoproteins ; HIV Infections - drug therapy ; HIV Infections - immunology ; Humans ; Immunology ; Male ; Pharmacology ; Regression analysis ; Sex Factors ; Young Adult
Is Part Of: Journal of acquired immune deficiency syndromes (1999), 2014-01, Vol.65 (1), p.e8-e16
Description: To describe the CD4 cell count at the start of combination antiretroviral therapy (cART) in low-income (LIC), lower middle-income (LMIC), upper middle-income (UMIC), and high-income (HIC) countries. Patients aged 16 years or older starting cART in a clinic participating in a multicohort collaboration spanning 6 continents (International epidemiological Databases to Evaluate AIDS and ART Cohort Collaboration) were eligible. Multilevel linear regression models were adjusted for age, gender, and calendar year; missing CD4 counts were imputed. In total, 379,865 patients from 9 LIC, 4 LMIC, 4 UMIC, and 6 HIC were included. In LIC, the median CD4 cell count at cART initiation increased by 83% from 80 to 145 cells/μL between 2002 and 2009. Corresponding increases in LMIC, UMIC, and HIC were from 87 to 155 cells/μL (76% increase), 88 to 135 cells/μL (53%), and 209 to 274 cells/μL (31%). In 2009, compared with LIC, median counts were 13 cells/μL [95% confidence interval (CI): -56 to +30] lower in LMIC, 22 cells/μL (-62 to +18) lower in UMIC, and 112 cells/μL (+75 to +149) higher in HIC. They were 23 cells/μL (95% CI: +18 to +28 cells/μL) higher in women than men. Median counts were 88 cells/μL (95% CI: +35 to +141 cells/μL) higher in countries with an estimated national cART coverage >80%, compared with countries with <40% coverage. Median CD4 cell counts at the start of cART increased 2000-2009 but remained below 200 cells/μL in LIC and MIC and below 300 cells/μL in HIC. Earlier start of cART will require substantial efforts and resources globally.
Publisher: United States: Lippincott Williams & Wilkins Ovid Technologies
Language: English
Identifier: ISSN: 1525-4135
EISSN: 1944-7884
DOI: 10.1097/qai.0b013e3182a39979
PMID: 24419071
CODEN: JDSRET
Source: MEDLINE
Free E Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Immunodeficiency at the start of combination antiretroviral therapy in low-, middle-, and high-income countries

Copyright Lippincott Williams & Wilkins Jan 1, 2014 ;ISSN: 1525-4135 ;EISSN: 1944-7884 ;DOI: 10.1097/qai.0b013e3182a39979 ;PMID: 24419071 ;CODEN: JDSRET

Searching Remote Databases, Please Wait