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Should we expect neurological symptoms in the SARS-CoV-2 epidemic?

Neurologia (Barcelona, Spain), 2020-04, Vol.35 (3), p.170-175 [Peer Reviewed Journal]

Copyright © 2020 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved. ;EISSN: 1578-1968 ;EISSN: 2173-5808 ;DOI: 10.1016/j.nrl.2020.03.001 ;PMID: 32299636

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  • Title:
    Should we expect neurological symptoms in the SARS-CoV-2 epidemic?
  • Author: Matías-Guiu, J ; Gomez-Pinedo, U ; Montero-Escribano, P ; Gomez-Iglesias, P ; Porta-Etessam, J ; Matias-Guiu, J A
  • Subjects: Animals ; Betacoronavirus ; Central Nervous System - virology ; Coronavirus Infections - complications ; Coronavirus Infections - physiopathology ; COVID-19 ; Disease Models, Animal ; Humans ; Mice ; Pandemics ; Pneumonia, Viral - complications ; Pneumonia, Viral - physiopathology ; SARS-CoV-2
  • Is Part Of: Neurologia (Barcelona, Spain), 2020-04, Vol.35 (3), p.170-175
  • Description: There is growing evidence that SARS-CoV-2 can gain access to the central nervous system (CNS). We revise the literature on coronavirus infection of the CNS associated with neurological diseases. Neurological symptoms were rarely reported in the SARS-CoV and MERS-CoV epidemics, although isolated cases were described. There are also reports of cases of neurological symptoms associated with CoV-OC43 and CoV-229E infection. The presence of neurological lesions, especially demyelinating lesions in the mouse hepatitis virus model, may explain the mechanisms by which coronaviruses enter the CNS, particularly those related with the immune response. This may explain the presence of coronavirus in patients with multiple sclerosis. We review the specific characteristics of SARS-CoV-2 and address the question of whether the high number of cases may be associated with greater CNS involvement. Although neurological symptoms are not frequent in coronavirus epidemics, the high number of patients with SARS-CoV-2 infection may explain the presence of the virus in the CNS and increase the likelihood of early- or delayed-onset neurological symptoms. Follow-up of patients affected by the SARS-CoV-2 epidemic should include careful assessment of the CNS.
  • Publisher: Spain
  • Language: English;Spanish
  • Identifier: EISSN: 1578-1968
    EISSN: 2173-5808
    DOI: 10.1016/j.nrl.2020.03.001
    PMID: 32299636
  • Source: MEDLINE
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