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New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease

International journal of molecular sciences, 2019-01, Vol.20 (1), p.187 [Tạp chí có phản biện]

2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2019 by the authors. 2019 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms20010187 ;PMID: 30621010

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Nhan đề:
New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease
Tác giả: Daiber, Andreas ; Xia, Ning ; Steven, Sebastian ; Oelze, Matthias ; Hanf, Alina ; Kröller-Schön, Swenja ; Münzel, Thomas ; Li, Huige
Chủ đề: Adipose tissue ; Air pollution ; Animals ; cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - enzymology ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - physiopathology ; Cardiovascular Diseases - therapy ; endothelial dysfunction ; eNOS uncoupling ; environmental stressors ; Epigenesis, Genetic ; Health risk assessment ; Humans ; inflammation ; Kindling ; Leukocytes ; life style/behavioral health risk factors ; Models, Biological ; Mortality ; Myocardial infarction ; NAD(P)H oxidase ; NADPH-diaphorase ; Nicotinamide ; Nicotinamide adenine dinucleotide ; Nitric oxide ; Nitric Oxide Synthase Type III - metabolism ; Nitric-oxide synthase ; Oxidation ; Oxidation-Reduction ; Oxidative stress ; Particulate matter ; Peroxynitrite ; Phagocytes ; Pollution ; Psychological stress ; Review ; Risk analysis ; Risk factors ; Social interactions ; Socioeconomic Factors ; Solid fuels ; Superoxide
Là 1 phần của: International journal of molecular sciences, 2019-01, Vol.20 (1), p.187
Mô tả: The Global Burden of Disease Study identified cardiovascular risk factors as leading causes of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism that is associated with most of these risk factors and stressors, and represents an early (subclinical) marker/predictor of atherosclerosis. Oxidative stress is a trigger of endothelial dysfunction and it is a hall-mark of cardiovascular diseases and of the risk factors/stressors that are responsible for their initiation. Endothelial function is largely based on endothelial nitric oxide synthase (eNOS) function and activity. Likewise, oxidative stress can lead to the loss of eNOS activity or even "uncoupling" of the enzyme by adverse regulation of well-defined "redox switches" in eNOS itself or up-/down-stream signaling molecules. Of note, not only eNOS function and activity in the endothelium are essential for vascular integrity and homeostasis, but also eNOS in perivascular adipose tissue plays an important role for these processes. Accordingly, eNOS protein represents an attractive therapeutic target that, so far, was not pharmacologically exploited. With our present work, we want to provide an overview on recent advances and future therapeutic strategies that could be used to target eNOS activity and function in cardiovascular (and other) diseases, including life style changes and epigenetic modulations. We highlight the redox-regulatory mechanisms in eNOS function and up- and down-stream signaling pathways (e.g., tetrahydrobiopterin metabolism and soluble guanylyl cyclase/cGMP pathway) and their potential pharmacological exploitation.
Nơi xuất bản: Switzerland: MDPI AG
Ngôn ngữ: English
Số nhận dạng: ISSN: 1422-0067
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms20010187
PMID: 30621010
Nguồn: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease

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