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Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men

PloS one, 2014-01, Vol.9 (1), p.e85805 [Tạp chí có phản biện]

COPYRIGHT 2014 Public Library of Science ;COPYRIGHT 2014 Public Library of Science ;2014. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2014 ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0085805 ;PMID: 24489673

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Nhan đề:
Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men
Tác giả: Finkle, William D ; Greenland, Sander ; Ridgeway, Gregory K ; Adams, John L ; Frasco, Melissa A ; Cook, Michael B ; Fraumeni, Jr, Joseph F ; Hoover, Robert N
Gong, Yan
Chủ đề: Age ; Age Factors ; Aged ; Androgens ; Carbolines - adverse effects ; Cardiovascular disease ; Cardiovascular diseases ; Comparative analysis ; Coronary artery disease ; Health risk assessment ; Health risks ; Heart ; Heart attack ; Heart diseases ; Hormone replacement therapy ; Humans ; Infarction ; Male ; Medical research ; Medicine ; Medicine, Experimental ; Men ; Middle Aged ; Myocardial infarction ; Myocardial Infarction - chemically induced ; Phosphodiesterase ; Phosphodiesterase 5 Inhibitors - adverse effects ; Piperazines - adverse effects ; Prescription Drugs - adverse effects ; Purines - adverse effects ; Risk ; Sildenafil ; Sildenafil Citrate ; Sulfones - adverse effects ; Tadalafil ; Testosterone ; Testosterone - adverse effects ; Therapy
Là 1 phần của: PloS one, 2014-01, Vol.9 (1), p.e85805
Mô tả: An association between testosterone therapy (TT) and cardiovascular disease has been reported and TT use is increasing rapidly. We conducted a cohort study of the risk of acute non-fatal myocardial infarction (MI) following an initial TT prescription (N = 55,593) in a large health-care database. We compared the incidence rate of MI in the 90 days following the initial prescription (post-prescription interval) with the rate in the one year prior to the initial prescription (pre-prescription interval) (post/pre). We also compared post/pre rates in a cohort of men prescribed phosphodiesterase type 5 inhibitors (PDE5I; sildenafil or tadalafil, N = 167,279), and compared TT prescription post/pre rates with the PDE5I post/pre rates, adjusting for potential confounders using doubly robust estimation. In all subjects, the post/pre-prescription rate ratio (RR) for TT prescription was 1.36 (1.03, 1.81). In men aged 65 years and older, the RR was 2.19 (1.27, 3.77) for TT prescription and 1.15 (0.83, 1.59) for PDE5I, and the ratio of the rate ratios (RRR) for TT prescription relative to PDE5I was 1.90 (1.04, 3.49). The RR for TT prescription increased with age from 0.95 (0.54, 1.67) for men under age 55 years to 3.43 (1.54, 7.56) for those aged ≥ 75 years (p trend = 0.03), while no trend was seen for PDE5I (p trend = 0.18). In men under age 65 years, excess risk was confined to those with a prior history of heart disease, with RRs of 2.90 (1.49, 5.62) for TT prescription and 1.40 (0.91, 2.14) for PDE5I, and a RRR of 2.07 (1.05, 4.11). In older men, and in younger men with pre-existing diagnosed heart disease, the risk of MI following initiation of TT prescription is substantially increased.
Nơi xuất bản: United States: Public Library of Science
Ngôn ngữ: English
Số nhận dạng: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0085805
PMID: 24489673
Nguồn: GFMER Free Medical Journals
MEDLINE
PubMed Central
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

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Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men

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