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Activation of YAP regulates muscle fiber size in a PKC-dependent mechanism during chick in vitro myogenesis

Journal of muscle research and cell motility, 2022-06, Vol.43 (2), p.73-86 [Peer Reviewed Journal]

The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 ;The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021. ;ISSN: 0142-4319 ;EISSN: 1573-2657 ;DOI: 10.1007/s10974-021-09608-8

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Title:
Activation of YAP regulates muscle fiber size in a PKC-dependent mechanism during chick in vitro myogenesis
Author: Gomes, Geyse ; Bagri, Kayo Moreira ; de Andrade Rosa, Ivone ; Jurberg, Arnon Dias ; Mermelstein, Claudia ; Costa, Manoel Luis
Subjects: Animal Anatomy ; Antibodies ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cell cycle ; Cell differentiation ; Cloning ; Cytoplasm ; Embryos ; Fibroblast growth factor ; Gene expression ; Histology ; Kinases ; Life Sciences ; Localization ; Morphology ; Motility ; Musculoskeletal system ; Myoblasts ; Myogenesis ; Myogenin ; Myotubes ; Original Paper ; Phenotypes ; Protein kinase C ; Proteins ; Proteomics ; Skeletal muscle ; Wnt protein ; Yes-associated protein
Is Part Of: Journal of muscle research and cell motility, 2022-06, Vol.43 (2), p.73-86
Description: The formation of skeletal muscle fibers is an intricate process controlled by a multitude of signaling pathways, including Wnt, Shh, and FGF. However, the role of the Hippo pathway during vertebrate myofiber formation has conflicting reports, which we decided to address in chick muscle cultures. We found that the transcriptional regulator Yes-associated protein (YAP) was highly concentrated within the nuclei of myoblasts. As cells differentiate into myotubes, YAP localization shifted to the cell cytoplasm in more mature myotubes. Treatment of cultures with XMU-MP-1 (XMU), a MST1/2 inhibitor, stimulated the nuclear localization of YAP in myoblasts and in myotubes, upregulated myogenin, and promoted myoblast fusion, ultimately resulting in the formation of large and fully striated multinucleated myotubes. The XMU-induced phenotype was blocked by the protein kinase C (PKC) inhibitor calphostin, which raises the possibility that the Hippo pathway controls the growth of skeletal muscle fibers through a PKC-dependent mechanism.
Publisher: Cham: Springer International Publishing
Language: English
Identifier: ISSN: 0142-4319
EISSN: 1573-2657
DOI: 10.1007/s10974-021-09608-8
Source: ProQuest Central

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Activation of YAP regulates muscle fiber size in a PKC-dependent mechanism during chick in vitro myogenesis

The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 ;The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021. ;ISSN: 0142-4319 ;EISSN: 1573-2657 ;DOI: 10.1007/s10974-021-09608-8

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