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The promise and peril of chemical probes

Nature chemical biology, 2015-08, Vol.11 (8), p.536-541 [Peer Reviewed Journal]

Copyright Nature Publishing Group Aug 2015 ;ISSN: 1552-4450 ;ISSN: 1552-4469 ;EISSN: 1552-4469 ;DOI: 10.1038/nchembio.1867 ;PMID: 26196764

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Title:
The promise and peril of chemical probes
Author: Arrowsmith, Cheryl H ; Audia, James E ; Austin, Christopher ; Baell, Jonathan ; Bennett, Jonathan ; Blagg, Julian ; Bountra, Chas ; Brennan, Paul E ; Brown, Peter J ; Bunnage, Mark E ; Buser-Doepner, Carolyn ; Campbell, Robert M ; Carter, Adrian J ; Cohen, Philip ; Copeland, Robert A ; Cravatt, Ben ; Dahlin, Jayme L ; Dhanak, Dashyant ; Edwards, Aled M ; Frederiksen, Mathias ; Frye, Stephen V ; Gray, Nathanael ; Grimshaw, Charles E ; Hepworth, David ; Howe, Trevor ; Huber, Kilian V M ; Jin, Jian ; Knapp, Stefan ; Kotz, Joanne D ; Kruger, Ryan G ; Lowe, Derek ; Mader, Mary M ; Marsden, Brian ; Mueller-Fahrnow, Anke ; Müller, Susanne ; O'Hagan, Ronan C ; Overington, John P ; Owen, Dafydd R ; Rosenberg, Saul H ; Roth, Bryan ; Roth, Brian ; Ross, Ruth ; Schapira, Matthieu ; Schreiber, Stuart L ; Shoichet, Brian ; Sundström, Michael ; Superti-Furga, Giulio ; Taunton, Jack ; Toledo-Sherman, Leticia ; Walpole, Chris ; Walters, Michael A ; Willson, Timothy M ; Workman, Paul ; Young, Robert N ; Zuercher, William J
Subjects: Biochemistry ; Biomedical research ; Biomedical Research - instrumentation ; Biomedical Research - methods ; Humans ; Information Dissemination - ethics ; Intellectual Property ; Internet ; Medical screening ; Medicin och hälsovetenskap ; Molecular Probes - chemistry ; Molecular Probes - pharmacology ; Molecular Weight ; Sensitivity and Specificity ; Small Molecule Libraries - chemistry ; Small Molecule Libraries - pharmacology
Is Part Of: Nature chemical biology, 2015-08, Vol.11 (8), p.536-541
Description: Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1552-4450
ISSN: 1552-4469
EISSN: 1552-4469
DOI: 10.1038/nchembio.1867
PMID: 26196764
Source: AUTh Library subscriptions: ProQuest Central
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The promise and peril of chemical probes

Copyright Nature Publishing Group Aug 2015 ;ISSN: 1552-4450 ;ISSN: 1552-4469 ;EISSN: 1552-4469 ;DOI: 10.1038/nchembio.1867 ;PMID: 26196764

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