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Next-generation stem cells - ushering in a new era of cell-based therapies

Nature reviews. Drug discovery, 2020-07, Vol.19 (7), p.463-479 [Peer Reviewed Journal]

COPYRIGHT 2020 Nature Publishing Group ;Springer Nature Limited 2020. ;ISSN: 1474-1776 ;EISSN: 1474-1784 ;DOI: 10.1038/s41573-020-0064-x ;PMID: 32612263

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Title:
Next-generation stem cells - ushering in a new era of cell-based therapies
Author: Kimbrel, Erin A ; Lanza, Robert
Subjects: Animals ; Antigens ; Bone marrow ; Cell Engineering - methods ; Clinical trials ; Drug Delivery Systems ; Gene Editing ; Gene therapy ; Genes ; Genetic Therapy - methods ; Health aspects ; Hematopoietic stem cells ; Humans ; Mutation ; Oncolytic Virotherapy - methods ; Proteins ; Regulatory approval ; Spyware ; Stem Cell Transplantation - methods ; Stem cells ; Stem Cells - cytology ; Transplantation ; Transplants & implants ; Tumors ; Viruses
Is Part Of: Nature reviews. Drug discovery, 2020-07, Vol.19 (7), p.463-479
Description: Naturally occurring stem cells isolated from humans have been used therapeutically for decades. This has primarily involved the transplantation of primary cells such as haematopoietic and mesenchymal stem cells and, more recently, derivatives of pluripotent stem cells. However, the advent of cell-engineering approaches is ushering in a new generation of stem cell-based therapies, greatly expanding their therapeutic utility. These next-generation stem cells are being used as 'Trojan horses' to improve the delivery of drugs and oncolytic viruses to intractable tumours and are also being engineered with angiogenic, neurotrophic and anti-inflammatory molecules to accelerate the repair of injured or diseased tissues. Moreover, gene therapy and gene editing technologies are being used to create stem cell derivatives with improved functionality, specificity and responsiveness compared with their natural counterparts. Here, we review these engineering approaches and areas in which they will help broaden the utility and clinical applicability of stem cells.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1474-1776
EISSN: 1474-1784
DOI: 10.1038/s41573-020-0064-x
PMID: 32612263
Source: MEDLINE
ProQuest Central

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Next-generation stem cells - ushering in a new era of cell-based therapies

COPYRIGHT 2020 Nature Publishing Group ;Springer Nature Limited 2020. ;ISSN: 1474-1776 ;EISSN: 1474-1784 ;DOI: 10.1038/s41573-020-0064-x ;PMID: 32612263

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