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Schizophrenia as a risk factor for cardiovascular and metabolic health outcomes: a comparative risk assessment

Epidemiology and psychiatric sciences, 2023-02, Vol.32, p.e8-e8, Article e8 [Peer Reviewed Journal]

Copyright © The Author(s), 2023. Published by Cambridge University Press ;Copyright © The Author(s), 2023. Published by Cambridge University Press. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2023 2023 The Author(s) ;ISSN: 2045-7960 ;EISSN: 2045-7979 ;DOI: 10.1017/S2045796023000045 ;PMID: 36756905

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  • Title:
    Schizophrenia as a risk factor for cardiovascular and metabolic health outcomes: a comparative risk assessment
  • Author: Ali, S. ; Santomauro, D. ; Ferrari, A. J ; Charlson, F.
  • Subjects: Cardiovascular disease ; Cause of Death ; Fatalities ; Humans ; Life Expectancy ; Mental disorders ; Mortality ; Original ; Original Article ; Psychiatry ; Risk Assessment ; Risk Factors ; Schizophrenia ; Schizophrenia - epidemiology ; Stroke - epidemiology
  • Is Part Of: Epidemiology and psychiatric sciences, 2023-02, Vol.32, p.e8-e8, Article e8
  • Description: Cardiometabolic diseases are responsible for the majority of premature deaths in people with schizophrenia. This study aimed to quantify the fatal burden of ischaemic heart disease (IHD), stroke and diabetes attributable to schizophrenia. Comparative Risk Assessment methodology from the Global Burden of Disease (GBD) study was used to calculate attributable burden; pooled relative risks (RRs) for IHD, stroke and diabetes were estimated via meta-regression, which were combined with GBD schizophrenia prevalence estimates to calculate the deaths and years of life lost (YLLs) caused by these health outcomes that were attributable to schizophrenia. The proportion of explained all-cause fatal burden and corresponding unexplained burden was also calculated. The pooled RRs for IHD, stroke and diabetes mortality were 2.36 [95% uncertainty interval (UI) 1.77 to 3.14], 1.86 (95% UI 1.36 to 2.54) and 4.08 (95% UI 3.80 to 4.38) respectively. Schizophrenia was responsible for around 50 000 deaths and almost 1.5 million YLLs globally in 2019 from these health outcomes combined. IHD, stroke and diabetes together explained around 13% of all deaths and almost 11% of all YLLs attributable to schizophrenia, resulting in 320 660 (95% UI 288 299 to 356 517) unexplained deaths and 12 258 690 (95% UI 10 925 426 to 13 713 646) unexplained YLLs. Quantifying the physical disease burden attributable to schizophrenia provides a means of capturing the substantial excess mortality associated with this disorder within the GBD framework, contributing to an important evidence base for healthcare planning and practice.
  • Publisher: Cambridge, UK: Cambridge University Press
  • Language: English;Italian
  • Identifier: ISSN: 2045-7960
    EISSN: 2045-7979
    DOI: 10.1017/S2045796023000045
    PMID: 36756905
  • Source: ProQuest One Psychology
    Journals@Ovid Open Access Journal Collection Rolling
    MEDLINE
    PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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