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Vascular permeability factor : a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration

The Journal of experimental medicine, 1990-12, Vol.172 (6), p.1535-1545 [Peer Reviewed Journal]

1991 INIST-CNRS ;ISSN: 0022-1007 ;EISSN: 1540-9538 ;DOI: 10.1084/jem.172.6.1535 ;PMID: 2258694 ;CODEN: JEMEAV

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Title:
Vascular permeability factor : a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
Author: CLAUSS, M ; GERLACH, M ; GERLACH, H ; BRETT, J ; WANG, F ; FAMILLETTI, P. C ; PAN, Y.-C. E ; OLANDER, J. V ; CONNOLLY, D. T ; STERN, D
Subjects: Amino Acid Sequence ; Analysis of the immune response. Humoral and cellular immunity ; Animals ; Biological and medical sciences ; Blood Coagulation Factors - biosynthesis ; Cell Line ; Cells, Cultured ; Chemotaxis, Leukocyte - drug effects ; Chromatography, High Pressure Liquid ; Chromatography, Ion Exchange ; Culture Media ; Endothelial Growth Factors - immunology ; Endothelial Growth Factors - isolation & purification ; Endothelial Growth Factors - pharmacology ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Guinea Pigs ; Humans ; Immune Sera ; Immunobiology ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - physiology ; Lymphokines - immunology ; Lymphokines - isolation & purification ; Lymphokines - pharmacology ; Mice ; Miscellaneous ; Molecular Sequence Data ; Osteosarcoma ; Recombinant Proteins - pharmacology ; Regulatory factors and their cellular receptors ; Sequence Homology, Nucleic Acid ; Thromboplastin ; Tumor Necrosis Factor-alpha - pharmacology ; Umbilical Veins ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors
Is Part Of: The Journal of experimental medicine, 1990-12, Vol.172 (6), p.1535-1545
Description: Systemic infusion of low concentrations of tumor necrosis factor/cachectin (TNF) into mice that bear TNF-sensitive tumors leads to activation of coagulation, fibrin formation, and occlusive thrombosis exclusively within the tumor vascular bed. To identify mechanisms underlying the localization of this vascular procoagulant response, a tumor-derived polypeptide has been purified to homogeneity from supernatants of murine methylcholanthrene A-induced fibrosarcomas that induces endothelial tissue factor synthesis and expression (half-maximal response at approximately 300 pM), and augments the procoagulant response to TNF in a synergistic fashion. This tumor-derived polypeptide was identified as the murine homologue of vascular permeability factor (VPF) based on similar mobility on SDS-PAGE, an homologous NH2-terminal amino acid sequence, and recognition by a monospecific antibody to guinea pig VPF. In addition, VPF was shown to induce monocyte activation, as evidenced by expression of tissue factor. Finally, VPF was shown to induce monocyte chemotaxis across collagen membranes and endothelial cell monolayers. Taken together, these results indicate that VPF can modulate the coagulant properties of endothelium and monocytes, and can promote monocyte migration into the tumor bed. This suggests one mechanism through which tumor-derived mediators can alter properties of the vessel wall.
Publisher: New York, NY: Rockefeller University Press
Language: English
Identifier: ISSN: 0022-1007
EISSN: 1540-9538
DOI: 10.1084/jem.172.6.1535
PMID: 2258694
CODEN: JEMEAV
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central

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Vascular permeability factor : a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration

1991 INIST-CNRS ;ISSN: 0022-1007 ;EISSN: 1540-9538 ;DOI: 10.1084/jem.172.6.1535 ;PMID: 2258694 ;CODEN: JEMEAV

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