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Naive and memory T cells show distinct pathways of lymphocyte recirculation

The Journal of experimental medicine, 1990-03, Vol.171 (3), p.801-817 [Peer Reviewed Journal]

1990 INIST-CNRS ;ISSN: 0022-1007 ;EISSN: 1540-9538 ;DOI: 10.1084/jem.171.3.801 ;PMID: 2307933 ;CODEN: JEMEAV

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  • Title:
    Naive and memory T cells show distinct pathways of lymphocyte recirculation
  • Author: MACKAY, C. R ; MARSTON, W. L ; DUDLER, L
  • Subjects: Animals ; Antigens, CD - analysis ; Biological and medical sciences ; Bromodeoxyuridine - metabolism ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Immunobiology ; Immunologic Memory ; Lymph - immunology ; Lymphocyte Activation ; Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation ; Phenotype ; Sheep ; T-Lymphocytes - immunology
  • Is Part Of: The Journal of experimental medicine, 1990-03, Vol.171 (3), p.801-817
  • Description: In this report, we have addressed two questions concerning immunological memory: the way in which naive and memory T cells recirculate through the body, and the intrinsic rate of division within the naive and memory populations. We identified naive and memory T cells in sheep by their cell surface phenotype and their ability to respond to recall antigen. Memory T cells were CD2hi, CD58hi, CD44hi, CD11ahi, and CD45R-, as pertains in man. T cells that crossed from blood to the tissues of the hind leg and accumulated in the popliteal afferent lymph were all of memory phenotype. Conversely, T cells in efferent lymph, 90% of which entered the lymph node (LN) via high endothelial venules (HEV), were mostly of the naive phenotype (CD2lo, CD58lo, CD44lo, CD11alo, and CD45R+). The marked enrichment of these two phenotypes in different recirculatory compartments indicated that memory T cells selectively traffic from blood to peripheral tissues to LN (via afferent lymph), whereas naive T cells selectively traffic from blood to LN (via HEV). We argue that the differential use of these two recirculation pathways probably optimizes lymphocyte interactions with antigen. The nonrandom distribution of T cell subsets in various recirculatory compartments may be related to the relative proportion of memory cells in each subset. In particular, gamma/delta T cells in blood were almost exclusively of memory phenotype, and accumulated preferentially in afferent, but not in efferent, lymph. Finally, using the bromo-deoxyuridine labeling technique, we found that at least a sizeable proportion of memory T cells, whether in blood or afferent lymph, were a dividing population of cells, whereas naive T cells were a nondividing population. This result supports an alternative model of lymphocyte memory that assumes that maintenance of memory requires persistent antigenic stimulation.
  • Publisher: New York, NY: Rockefeller University Press
  • Language: English
  • Identifier: ISSN: 0022-1007
    EISSN: 1540-9538
    DOI: 10.1084/jem.171.3.801
    PMID: 2307933
    CODEN: JEMEAV
  • Source: GFMER Free Medical Journals
    MEDLINE
    PubMed Central
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