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Novel Biomarkers, ST-Elevation Resolution, and Clinical Outcomes Following Primary Percutaneous Coronary Intervention

Journal of the American Heart Association, 2020-07, Vol.9 (13), p.e016033-e016033 [Peer Reviewed Journal]

2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. ;ISSN: 2047-9980 ;EISSN: 2047-9980 ;DOI: 10.1161/JAHA.120.016033 ;PMID: 32552321

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Title:
Novel Biomarkers, ST-Elevation Resolution, and Clinical Outcomes Following Primary Percutaneous Coronary Intervention
Author: Shavadia, Jay S ; Granger, Christopher B ; Alemayehu, Wendimagegn ; Westerhout, Cynthia M ; Povsic, Thomas J ; Van Diepen, Sean ; Defilippi, Christopher ; Armstrong, Paul W
Subjects: Aged ; biomarkers ; Biomarkers - blood ; Coronary Circulation ; Female ; Humans ; Male ; microvascular reperfusion ; Middle Aged ; Natriuretic Peptide, Brain - blood ; Original Research ; Peptide Fragments - blood ; Percutaneous Coronary Intervention - adverse effects ; Platelet Activation ; primary percutaneous coronary intervention ; Principal Component Analysis ; Randomized Controlled Trials as Topic ; Recovery of Function ; Risk Assessment ; Risk Factors ; ST Elevation Myocardial Infarction - blood ; ST Elevation Myocardial Infarction - diagnosis ; ST Elevation Myocardial Infarction - physiopathology ; ST Elevation Myocardial Infarction - therapy ; ST‐elevation resolution ; ST‐segment–elevation myocardial infarction ; Time Factors ; Treatment Outcome
Is Part Of: Journal of the American Heart Association, 2020-07, Vol.9 (13), p.e016033-e016033
Description: Background Despite restoration of epicardial flow following primary percutaneous coronary intervention (PPCI), microvascular reperfusion as reflected by ST-elevation resolution (ST-ER) resolution remains variable and its pathophysiology remains unclear. Methods and Results Using principal component analyses, we explored associations between 91 serum biomarkers drawn before PPCI clustered into 14 pathobiologic processes (including NT-proBNP [N-terminal pro-B-type natriuretic peptide] as an independent cluster), and (1) ST-ER resolution ≥50% versus <50%; and (2) 90-day composite of death, shock, and heart failure. Network analyses were performed to understand interbiomarker relationships between the ST-ER groups. Among the 1160 patients studied, 861 (74%) had ST-ER ≥50% at a median 40 (interquartile range, 23-70) minutes following PPCI, yet both groups had comparable post-PPCI TIMI (Thrombolysis in Myocardial Infarction) grade 3 flow (86.6% versus 82.9%; =0.25). ST-ER ≥50% was associated with significantly lower pre-PPCI concentrations of platelet activation cluster (particularly P-selectin, von Willebrand factor, and platelet-derived growth factor A) and NT-proBNP, including after risk adjustment. Across both ST-ER groups, strong interbiomarker relationships were noted between pathways indicative of myocardial stretch, platelet activation, and inflammation, whereas with ST-ER <50% correlations between iron homeostasis and inflammation were observed. Of all 14 biomarker clusters, only NT-proBNP was significantly associated with the 90-day clinical composite. Conclusions Suboptimal ST-ER is common despite achieving post-PPCI TIMI grade 3 flow. The cluster of platelet activation proteins and NT-proBNP were strongly correlated with suboptimal ST-ER and NT-proBNP was independently associated with 90-day outcomes. This analysis provides insights into the pathophysiology of microvascular reperfusion in ST-segment-elevation myocardial infarction and suggests novel pre-PPCI risk targets potentially amenable to enhancing tissue-level reperfusion following PPCI.
Publisher: England: John Wiley and Sons Inc
Language: English
Identifier: ISSN: 2047-9980
EISSN: 2047-9980
DOI: 10.1161/JAHA.120.016033
PMID: 32552321
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Wiley Online Library Open Access
ROAD: Directory of Open Access Scholarly Resources
DOAJ Directory of Open Access Journals

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Novel Biomarkers, ST-Elevation Resolution, and Clinical Outcomes Following Primary Percutaneous Coronary Intervention

2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. ;ISSN: 2047-9980 ;EISSN: 2047-9980 ;DOI: 10.1161/JAHA.120.016033 ;PMID: 32552321

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