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Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease

European heart journal, 2021-10, Vol.42 (40), p.4180-4188 [Peer Reviewed Journal]

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com. 2021 ;Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com. ;ISSN: 0195-668X ;ISSN: 1522-9645 ;EISSN: 1522-9645 ;DOI: 10.1093/eurheartj/ehab505 ;PMID: 34374755

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  • Title:
    Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease
  • Author: Wang, Ningjian ; Sun, Ying ; Zhang, Haojie ; Wang, Bin ; Chen, Chi ; Wang, Yuying ; Chen, Jie ; Tan, Xiao ; Zhang, Jihui ; Xia, Fangzhen ; Qi, Lu ; Lu, Yingli
  • Subjects: Atrial fibrillation ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - etiology ; Cohort Studies ; Coronary Disease - epidemiology ; Coronary Disease - etiology ; Coronary heart disease ; Genetic risk ; Heart Failure ; Humans ; Lifestyle ; Medicin och hälsovetenskap ; Night shift ; Risk Factors ; Shift Work Schedule
  • Is Part Of: European heart journal, 2021-10, Vol.42 (40), p.4180-4188
  • Description: Abstract Aims The aim of this study was to test whether current and past night shift work was associated with incident atrial fibrillation (AF) and whether this association was modified by genetic vulnerability. Its associations with coronary heart disease (CHD), stroke, and heart failure (HF) were measured as a secondary aim. Methods and results This cohort study included 283 657 participants in paid employment or self-employed without AF and 276 009 participants free of CHD, stroke, and HF at baseline in the UK Biobank. Current and lifetime night shift work information was obtained. Cox proportional hazard models were used. Weighted genetic risk score for AF was calculated. During a median follow-up of 10.4 years, 5777 incident AF cases were documented. From ‘day workers’, ‘shift but never/rarely night shifts’, and ‘some night shifts’ to ‘usual/permanent night shifts’, there was a significant increasing trend in the risk of incident AF (P for trend 0.013). Usual or permanent night shifts were associated with the highest risk [hazard ratio (HR) 1.16, 95% confidence interval (CI) 1.02–1.32]. Considering a person’s lifetime work schedule and compared with shift workers never working nights, participants with a duration over 10 years and an average 3–8 nights/month frequency of night shift work exposure possessed higher AF risk (HR 1.18, 95% CI 0.99–1.40 and HR 1.22, 95% CI 1.02–1.45, respectively). These associations between current and lifetime night shifts and AF were not modified by genetic predisposition to AF. Usual/permanent current night shifts, ≥10 years and 3–8 nights/month of lifetime night shifts were significantly associated with a higher risk of incident CHD (HR 1.22, 95% CI 1.11–1.35, HR 1.37, 95% CI 1.20–1.58 and HR 1.35, 95% CI 1.18–1.55, respectively). These associations in stroke and HF were not significant. Conclusion Both current and lifetime night shift exposures were associated with increased AF risk, regardless of genetic AF risk. Night shift exposure also increased the risk of CHD but not stroke or HF. Whether decreasing night shift work frequency and duration might represent another avenue to improve heart health during working life and beyond warrants further study. Graphical Abstract This study demonstrates that both current and lifetime night shift exposures were associated with increased risk of atrial fibrillation and coronary heart disease.
  • Publisher: England: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0195-668X
    ISSN: 1522-9645
    EISSN: 1522-9645
    DOI: 10.1093/eurheartj/ehab505
    PMID: 34374755
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    Alma/SFX Local Collection
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