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Blood pressure status, trajectories and cardiovascular disease: the CoLaus|PsyCoLaus prospective study

Open heart, 2024-02, Vol.11 (1), p.e002556 [Peer Reviewed Journal]

Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. ;2024 Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 2053-3624 ;ISSN: 2398-595X ;EISSN: 2053-3624 ;DOI: 10.1136/openhrt-2023-002556 ;PMID: 38388190

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  • Title:
    Blood pressure status, trajectories and cardiovascular disease: the CoLaus|PsyCoLaus prospective study
  • Author: Chocron, Yaniv ; Rousakis, Markos ; Vollenweider, Peter ; Vaucher, Julien ; Marques-Vidal, Pedro-Manuel
  • Subjects: Alcohol ; Antihypertensives ; Blood pressure ; Blood Pressure - physiology ; Body mass index ; Cardiac risk factors and prevention ; Cardiovascular disease ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Diabetes ; Epidemiology ; global health ; Glucose ; Humans ; Hypertension ; Hypertension - diagnosis ; Hypertension - drug therapy ; Hypertension - epidemiology ; Medical prognosis ; Missing data ; Mortality ; Overweight ; Population-based studies ; Prospective Studies ; Risk Factors
  • Is Part Of: Open heart, 2024-02, Vol.11 (1), p.e002556
  • Description: BackgroundHigh blood pressure (BP) is a major risk factor for cardiovascular disease (CVD). Adequate treatment of high BP should reduce the risk of CVD, but this association has seldom been assessed in a general population setting.MethodsPopulation-based prospective study conducted in Lausanne, Switzerland, with a follow-up between 2003 and 2021. Participants were categorised as normal BP, untreated high BP, treated and uncontrolled BP and treated and controlled BP. Total and CVD mortality as well as any CVD event were assessed.Results5341 participants (65% normal, 17.4% untreated, 8.8% treated and uncontrolled and 8.8% treated and controlled) were included. After a median follow-up of 14 years (IQR: 11–15), 575 CVD events occurred. Relative to participants with normal BP, multivariable-adjusted HRs (and 95% CI) for total CVD were 1.38 (1.11 to 1.72) for untreated, 1.35 (1.04 to 1.76) for treated and uncontrolled and 1.50 (1.15 to 1.95) for treated and controlled. The corresponding HRs for CVD mortality (112 events) were 0.94 (0.52 to 1.70), 1.77 (1.00 to 3.12) and 2.52 (1.50 to 4.23), respectively. For total mortality (677 events), the HRs were 1.24 (1.01 to 1.52), 1.26 (0.99 to 1.60) and 1.27 (0.99 to 1.62), respectively. Sensitivity analysis using BP status during a 5-year period and categorising participants as always normal, always treated and uncontrolled, always treated and controlled and other led to similar findings.ConclusionOver a long follow-up period of 14 years, BP control was not associated with reduction of CVD events, CVD-related or total mortality. This finding should help define further studies on factors affecting CVD and mortality in people treated for hypertension in the general population.
  • Publisher: England: British Cardiovascular Society
  • Language: English
  • Identifier: ISSN: 2053-3624
    ISSN: 2398-595X
    EISSN: 2053-3624
    DOI: 10.1136/openhrt-2023-002556
    PMID: 38388190
  • Source: BMJ Open Access Journals
    MEDLINE
    Open Access: Freely Accessible Journals by multiple vendors
    PubMed Central
    Alma/SFX Local Collection
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
    DOAJ Directory of Open Access Journals
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