Ngôn ngữ:

Collective cell durotaxis emerges from long-range intercellular force transmission

Science (American Association for the Advancement of Science), 2016-09, Vol.353 (6304), p.1157-1161 [Tạp chí có phản biện]

Copyright © 2016 American Association for the Advancement of Science ;Copyright © 2016, American Association for the Advancement of Science. ;Copyright © 2016, American Association for the Advancement of Science ;info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/3.0/es/ ;ISSN: 0036-8075 ;EISSN: 1095-9203 ;DOI: 10.1126/science.aaf7119 ;PMID: 27609894 ;CODEN: SCIEAS

Tài liệu số/Tài liệu điện tử

Trích dẫn Trích dẫn bởi

Gửi đến

Nhan đề:
Collective cell durotaxis emerges from long-range intercellular force transmission
Tác giả: Sunyer, Raimon ; Conte, Vito ; Escribano, Jorge ; Elosegui-Artola, Alberto ; Labernadie, Anna ; Valon, Léo ; Navajas, Daniel ; García-Aznar, José Manuel ; Muñoz, José J. ; Roca-Cusachs, Pere ; Trepat, Xavier
Chủ đề: Adhesion ; Cancer ; Cancer cells ; Cell Line ; Cellular biology ; Clusters ; Cèl·lules canceroses ; Enginyeria biomèdica ; Epithelial Cells - physiology ; Extracellular Matrix ; Fibrosis ; Humans ; Intercellular Junctions - physiology ; Matrix ; Microscopy, Phase-Contrast ; Migration ; Motors ; Myosins - physiology ; Phenomenology ; Taxis Response ; Wound healing ; Àrees temàtiques de la UPC
Là 1 phần của: Science (American Association for the Advancement of Science), 2016-09, Vol.353 (6304), p.1157-1161
Mô tả: The ability of cells to follow gradients of extracellular matrix stiffness—durotaxis—has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated constituent cells did not. This emergent mode of directed collective cell migration applied to a variety of epithelial cell types, required the action of myosin motors, and originated from supracellular transmission of contractile physical forces. To explain the observed phenomenology, we developed a generalized clutch model in which local stick-slip dynamics of cell-matrix adhesions was integrated to the tissue level through cell-cell junctions. Collective durotaxis is far more efficient than single-cell durotaxis; it thus emerges as a robust mechanism to direct cell migration during development, wound healing, and collective cancer cell invasion.
Nơi xuất bản: United States: American Association for the Advancement of Science
Ngôn ngữ: English
Số nhận dạng: ISSN: 0036-8075
EISSN: 1095-9203
DOI: 10.1126/science.aaf7119
PMID: 27609894
CODEN: SCIEAS
Nguồn: Recercat

Trở lại danh sách kết quả


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Collective cell durotaxis emerges from long-range intercellular force transmission

Đang tìm Cơ sở dữ liệu bên ngoài...