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Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application

Stem cells international, 2018-01, Vol.2018, p.3057624-12 [Peer Reviewed Journal]

Copyright © 2018 Mengyuan Wang et al. ;COPYRIGHT 2018 COPYRIGHT 2010 SAGE-Hindawi Access to Research ;COPYRIGHT 2018 Hindawi Limited ;Copyright © 2018 Mengyuan Wang et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ;Copyright © 2018 Mengyuan Wang et al. 2018 ;ISSN: 1687-966X ;ISSN: 1687-9678 ;EISSN: 1687-9678 ;DOI: 10.1155/2018/3057624 ;PMID: 30013600

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Title:
Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application
Author: Wang, Mengyuan ; Yuan, Quan ; Xie, Liang
Yu, Bo ; Bo Yu
Subjects: Adaptive systems ; Autocrine signalling ; B cells ; Bone marrow ; Cell self-renewal ; Chemokines ; Clinical trials ; Cytokines ; Diabetes ; Disease ; Feasibility studies ; Growth factors ; Immune system ; Immunomodulation ; Immunoregulation ; Immunosuppression ; Immunotherapy ; Inflammation ; Lupus ; Lymphocytes ; Mediation ; Medical research ; Medicine, Experimental ; Mesenchyme ; Metabolism ; Molecular chains ; Multiple sclerosis ; Nitric oxide ; Paracrine signalling ; Physiological aspects ; Physiological effects ; Properties (attributes) ; Regeneration ; Review ; Stem cells ; Transplants & implants ; Tumor necrosis factor-TNF
Is Part Of: Stem cells international, 2018-01, Vol.2018, p.3057624-12
Description: Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties via interaction with immune cells in both innate and adaptive immune systems, leading to immunosuppression of various effector functions. Numerous bioactive molecules secreted by MSCs, particularly cytokines, growth factors, and chemokines, exert autocrine/paracrine effects that modulate the physiological processes of MSCs. These invaluable virtues of MSCs provide new insight into potential treatments for tissue damage and inflammation. In particular, their extensive immunosuppressive properties are being explored for promising therapeutic application in immune disorders. Recently, clinical trials for MSC-mediated therapies have rapidly developed for immune-related diseases following reports from preclinical studies declaring their therapeutic safety and efficacy. Though immunotherapy of MSCs remains controversial, these clinical trials pave the way for their widespread therapeutic application in immune-based diseases. In this review, we will summarize and update the latest research findings and clinical trials on MSC-based immunomodulation.
Publisher: United States: Hindawi
Language: English
Identifier: ISSN: 1687-966X
ISSN: 1687-9678
EISSN: 1687-9678
DOI: 10.1155/2018/3057624
PMID: 30013600
Source: PubMed Central
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application

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