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Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States

PloS one, 2011-02, Vol.6 (2), p.e16103-e16103 [Peer Reviewed Journal]

COPYRIGHT 2011 Public Library of Science ;COPYRIGHT 2011 Public Library of Science ;2011 Simanek et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Simanek et al. 2011 ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0016103 ;PMID: 21379581

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Title:
Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States
Author: Simanek, Amanda M ; Dowd, Jennifer Beam ; Pawelec, Graham ; Melzer, David ; Dutta, Ambarish ; Aiello, Allison E
Hernandez, Adrian
Subjects: Adult ; Aged ; Aged, 80 and over ; Analysis ; Bacterial infections ; Bioindicators ; Biology ; C-reactive protein ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Cause of Death ; Chronic illnesses ; Confidence intervals ; Cytomegalovirus ; Cytomegalovirus - isolation & purification ; Cytomegalovirus - physiology ; Cytomegalovirus infections ; Cytomegalovirus Infections - blood ; Cytomegalovirus Infections - complications ; Cytomegalovirus Infections - epidemiology ; Cytomegalovirus Infections - mortality ; Diabetes ; Female ; Health aspects ; Health risk assessment ; Health risks ; Humans ; Infections ; Inflammation ; Inflammation - blood ; Inflammation - complications ; Inflammation - epidemiology ; Inflammation - mortality ; Male ; Mediation ; Medical research ; Medicine ; Medicine, Experimental ; Middle Aged ; Mortality ; Nutrition ; Nutrition Surveys ; Risk ; Seroepidemiologic Studies ; Statistical analysis ; United States - epidemiology
Is Part Of: PloS one, 2011-02, Vol.6 (2), p.e16103-e16103
Description: Studies have suggested that CMV infection may influence cardiovascular disease (CVD) risk and mortality. However, there have been no large-scale examinations of these relationships among demographically diverse populations. The inflammatory marker C-reactive protein (CRP) is also linked with CVD outcomes and mortality and may play an important role in the pathway between CMV and mortality. We utilized a U.S. nationally representative study to examine whether CMV infection is associated with all-cause and CVD-related mortality. We also assessed whether CRP level mediated or modified these relationships. Data come from subjects ≥ 25 years of age who were tested for CMV and CRP level and were eligible for mortality follow-up on December 31(st), 2006 (N = 14153) in the National Health and Nutrition Examination Survey (NHANES) III (1988-1994). Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for all-cause and CVD-related mortality by CMV serostatus. After adjusting for multiple confounders, CMV seropositivity remained statistically significantly associated with all-cause mortality (HR 1.19, 95% CI: 1.01, 1.41). The association between CMV and CVD-related mortality did not achieve statistical significance after confounder adjustment. CRP did not mediate these associations. However, CMV seropositive individuals with high CRP levels showed a 30.1% higher risk for all-cause mortality and 29.5% higher risk for CVD-related mortality compared to CMV seropositive individuals with low CRP levels. CMV was associated with a significant increased risk for all-cause mortality and CMV seropositive subjects who also had high CRP levels were at substantially higher risk for both for all-cause and CVD-related mortality than subjects with low CRP levels. Future work should target the mechanisms by which CMV infection and low-level inflammation interact to yield significant impact on mortality.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0016103
PMID: 21379581
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Public Library of Science
ProQuest Central
DOAJ Directory of Open Access Journals

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Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States

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