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Genome-Wide Analysis of the UGT Gene Family and Identification of Flavonoids in Broussonetia papyrifera

Molecules (Basel, Switzerland), 2021-06, Vol.26 (11), p.3449 [Peer Reviewed Journal]

2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021 by the authors. 2021 ;ISSN: 1420-3049 ;EISSN: 1420-3049 ;DOI: 10.3390/molecules26113449 ;PMID: 34204142

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  • Title:
    Genome-Wide Analysis of the UGT Gene Family and Identification of Flavonoids in Broussonetia papyrifera
  • Author: Wang, Fenfen ; Su, Yalei ; Chen, Naizhi ; Shen, Shihua
  • Subjects: Amino acids ; antioxidant activity ; Antioxidants ; Biosynthesis ; BpUGTs ; Broussonetia ; Broussonetia papyrifera ; Cancer ; Conserved sequence ; Deciduous trees ; Enzymes ; flavonoid ; Flavonoids ; Food sources ; Genes ; Genomes ; Herbal medicine ; Mass spectrometry ; Metabolites ; Pattern analysis ; Phenols ; Phylogenetics ; Phylogeny ; polyphenols ; Proteins ; Scientific imaging ; Secondary metabolites ; Subgroups ; Substrates
  • Is Part Of: Molecules (Basel, Switzerland), 2021-06, Vol.26 (11), p.3449
  • Description: Broussonetia papyrifera is a multifunctional deciduous tree that is both a food and a source of traditional Chinese medicine for both humans and animals. Further analysis of the UGT gene family is of great significance to the utilization of B. papyrifera. The substrates of plant UGT genes include highly diverse and complex chemicals, such as flavonoids and terpenes. In order to deepen our understanding of this family, a comprehensive analysis was performed. Phylogenetic analysis showed that 155 BpUGTs were divided into 15 subgroups. A conserved motif analysis showed that BpUGT proteins in the same subgroups possessed similar motif structures. Tandem duplication was the primary driving force for the expansion of the BpUGT gene family. The global promoter analysis indicated that they were associated with complex hormone regulatory networks and the stress response, as well as the synthesis of secondary metabolites. The expression pattern analysis showed that the expression level of BpUGTs in leaves and roots was higher than that in fruits and stems. Next, we determined the composition and content of flavonoids, the main products of the BpUGT reaction. A total of 19 compounds were isolated and analyzed by UPLC-ESI-MS/MS in 3 species of Broussonetia including B. kazinoki, B. papyrifera, and B. kazinoki × B. papyrifera, and the number of compounds was different in these 3 species. The total flavonoid content and antioxidant capacities of the three species were analyzed respectively. All assays exhibited the same trend: the hybrid paper mulberry showed a higher total flavonoid content, a higher total phenol content and higher antioxidant activity than the other two species. Overall, our study provides valuable information for understanding the function of BpUGTs in the biosynthesis of flavonoids.
  • Publisher: Basel: MDPI AG
  • Language: English
  • Identifier: ISSN: 1420-3049
    EISSN: 1420-3049
    DOI: 10.3390/molecules26113449
    PMID: 34204142
  • Source: Open Access: PubMed Central
    Geneva Foundation Free Medical Journals at publisher websites
    Alma/SFX Local Collection
    ProQuest Central
    DOAJ Directory of Open Access Journals
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