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Variability of Urinary Phthalate Metabolite and Bisphenol A Concentrations before and during Pregnancy

Environmental health perspectives, 2012-05, Vol.120 (5), p.739-745 [Peer Reviewed Journal]

2015 INIST-CNRS ;COPYRIGHT 2012 National Institute of Environmental Health Sciences ;COPYRIGHT 2012 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences May 2012 ;2012 ;ISSN: 0091-6765 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.1104139 ;PMID: 22262702 ;CODEN: EVHPAZ

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  • Title:
    Variability of Urinary Phthalate Metabolite and Bisphenol A Concentrations before and during Pregnancy
  • Author: Braun, Joe M. ; Smith, Kristen W. ; Williams, Paige L. ; Calafat, Antonia M. ; Berry, Katharine ; Ehrlich, Shelley ; Hauser, Russ
  • Subjects: Adolescent ; Adult ; Arithmetic mean ; Benzhydryl Compounds ; Biological and medical sciences ; Bisphenol A ; Bisphenols ; Boston ; Business publications audits ; Chemical hazards ; Children's Health ; Classification ; Environment. Living conditions ; Environmental health ; Female ; Health ; Health aspects ; Humans ; Medical sciences ; Metabolites ; Middle Aged ; Phenols - blood ; Phthalates ; Phthalic Acids - urine ; Pregnancy ; Pregnant women ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Replication ; Surrogacy ; Toxicology ; Urine ; Young Adult
  • Is Part Of: Environmental health perspectives, 2012-05, Vol.120 (5), p.739-745
  • Description: Background: Gestational phthalate and bisphenol A (BPA) exposure may increase the risk of adverse maternal/child health outcomes, but there are few data on the variability of urinary biomarkers before and during pregnancy. Objective: We characterized the variability of urinary phthalate metabolite and BPA concentrations before and during pregnancy and the ability of a single spot urine sample to classify average gestational exposure, METHODS: We collected 1,001 urine samples before and during pregnancy from 137 women who were partners in couples attending a Boston fertility clinic and who had a live birth. Women provided spot urine samples before (n ≥ 2) and during (n ≥ 2) pregnancy. We measured urinary concentrations of monoethyi phthalate (MEP), mono-n-butyl phthalate (MBP), mono-iso-butyl phthalate, monobenzyl phthalate (MBzP), four metabolites of di-(2-ethylhexyi) phthalate (DEHP),. and BPA. After adjusting for specific gravity, we characterized biomarker variability using intraclass correlation coefficients (ICCs) and conducted several surrogate category analyses to determine whether a single spot urine sample could adequately classify average gestational exposure. Results: Absolute concentrations of phthalate metabolites and BPA were similar before and during pregnancy. Variability was higher during pregnancy than before pregnancy for BPA and MBzP, but similar during and before pregnancy for MBP, MEP, and EDEHP. During pregnancy, MEP (ICC = 0.50) and MBP (ICC = 0.45) were less variable than BPA (ICC = 0.12), MBzP (ICC = 0.25), and XDEHP metabolites (ICC = 0.08). Surrogate analyses suggested that a single spot urine sample may reasonably classify MEP and MBP concentrations during pregnancy, but more than one sample may be necessary for MBzP, DEHP, and BPA. Conclusions: Urinary phthalate metabolites and BPA concentrations were variable before and during pregnancy, but the magnitude of variability was biomarker specific. A single spot urine sample adequately classified MBP and MEP concentrations during pregnancy. The present results may be related to unique features of the women studied, and replication in other pregnancy cohorts is recommended.
  • Publisher: Research Triangle Park, NC: National Institute of Environmental Health Sciences
  • Language: English
  • Identifier: ISSN: 0091-6765
    EISSN: 1552-9924
    DOI: 10.1289/ehp.1104139
    PMID: 22262702
    CODEN: EVHPAZ
  • Source: U.S. Government Documents
    MEDLINE
    PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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