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The galectin lattice at a glance
Journal of cell science, 2015-07, Vol.128 (13), p.2213-2219
[Peer Reviewed Journal]
2015. Published by The Company of Biologists Ltd. ;ISSN: 0021-9533 ;EISSN: 1477-9137 ;DOI: 10.1242/jcs.151159 ;PMID: 26092931
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Title:
The galectin lattice at a glance
Author:
Nabi, Ivan R
;
Shankar, Jay
;
Dennis, James W
Subjects:
Animals
;
Galectins - chemistry
;
Galectins - metabolism
;
Humans
;
Immunity
;
Neoplasms - metabolism
;
Polymers - metabolism
;
Protein Kinases - metabolism
;
Receptors, Antigen, T-Cell - metabolism
Is Part Of:
Journal of cell science, 2015-07, Vol.128 (13), p.2213-2219
Description:
Galectins are a family of widely expressed β-galactoside-binding lectins in metazoans. The 15 mammalian galectins have either one or two conserved carbohydrate recognition domains (CRDs), with galectin-3 being able to pentamerize; they form complexes that crosslink glycosylated ligands to form a dynamic lattice. The galectin lattice regulates the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids. The galectin lattice also regulates the selection, activation and arrest of T cells, receptor kinase signaling and the functionality of membrane receptors, including the glucagon receptor, glucose and amino acid transporters, cadherins and integrins. The affinity of transmembrane glycoproteins to the galectin lattice is proportional to the number and branching of their N-glycans; with branching being mediated by Golgi N-acetylglucosaminyltransferase-branching enzymes and the supply of UDP-GlcNAc through metabolite flux through the hexosamine biosynthesis pathway. The relative affinities of glycoproteins for the galectin lattice depend on the activities of the Golgi enzymes that generate the epitopes of their ligands and, thus, provide a means to analyze biological function of lectins and of the 'glycome' more broadly.
Publisher:
England
Language:
English
Identifier:
ISSN: 0021-9533
EISSN: 1477-9137
DOI: 10.1242/jcs.151159
PMID: 26092931
Source:
GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection
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