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The relation between gallstone disease and cardiovascular disease

Scientific reports, 2017-11, Vol.7 (1), p.15104-8, Article 15104 [Peer Reviewed Journal]

2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2017 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-017-15430-5 ;PMID: 29118437

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  • Title:
    The relation between gallstone disease and cardiovascular disease
  • Author: Fan, Lai Lai ; Chen, Bai Hui ; Dai, Zhi Juan
  • Subjects: Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - mortality ; Cohort Studies ; Family medical history ; Female ; Gallstones ; Gallstones - complications ; Humans ; Male ; Public health ; Risk Assessment - methods ; Risk Assessment - statistics & numerical data ; Risk Factors ; Sex Factors ; Survival Rate
  • Is Part Of: Scientific reports, 2017-11, Vol.7 (1), p.15104-8, Article 15104
  • Description: Gallstone disease (GD) is a common digestive disorder that shares many risk factors with cardiovascular disease (CVD). CVD is an important public health issue that encompasses a large percentage of overall mortality. Several recent studies have suggested an association between GD and CVD, while others have not. In this report, we present a meta-analysis of cohort studies to assess the association between GD and CVD. We included eight studies published from 1980 to 2017, including nearly one million participants. The pooled relative risk (RR, 95% confidence interval [CI]) from the random-effects model associates with GD is 1.23 (95% CI: 1.17-1.30) for fatal and nonfatal CVD events. The pooled RR from the random-effects model of CVD events in female patients with GD is 1.24 (95% CI: 1.16-1.32). In male GD patients, the pooled RR from the random-effects model for CVD is 1.18 (95% CI: 1.06-1.31). Our meta-analysis demonstrates a substantially increased risk of fatal and nonfatal CVD events among patients with a medical history of GD. We suggest that interested investigators should further pursue the subject. In addition, both male and female patients with GD have a risk of CVD, and women have a higher risk than men.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 2045-2322
    EISSN: 2045-2322
    DOI: 10.1038/s41598-017-15430-5
    PMID: 29118437
  • Source: MEDLINE
    PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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