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Tumor Suppressor Genes

Holland‐Frei Cancer Medicine, 2017, p.1-15

Copyright © 2023 John Wiley & Sons, Inc. ;Copyright © 2017 John Wiley & Sons, Inc. ;ISBN: 9781118934692 ;ISBN: 1118934695 ;EISBN: 1119000823 ;EISBN: 9781119000822 ;DOI: 10.1002/9781119000822.hfcm005.pub2 ;DOI: 10.1002/9781119000822.hfcm005

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  • Title:
    Tumor Suppressor Genes
  • Author: Bunz, Fred ; Vogelstein, Bert ; Vogelstein, Bert
  • Holland, James F ; Hong, Waun Ki ; Bast, Robert C ; Kufe, Donald W ; Weichselbaum, Ralph R ; Piccart‐Gebart, Martine ; Hait, William N ; Wang, Hongyang ; Pollock, Raphael E ; Croce, Carlo M
  • Is Part Of: Holland‐Frei Cancer Medicine, 2017, p.1-15
  • Description: Cancer is a genetic disease caused by alterations in proto‐oncogenes and tumor suppressor genes. Oncogenes, the first type of gene to be associated with cancer, are activated by somatic mutations and promote unregulated cell growth. In contrast, tumor suppressor genes encode proteins that maintain tissue homeostasis and are inactivated in tumors. Inactivated tumor suppressor genes can be acquired by somatic mutation, during the life of an individual, or transmitted via the germline from one generation to the next, causing familial cancer predisposition syndromes. Tumor suppressor genes thus provide a conceptual link between inherited cancer risk and sporadic cancers.
    Cancer is a genetic disease. Mutations and other alterations in growth promoting genes (oncogenes) and tumor suppressor genes can accumulate during the lifetime of a normal cell resulting in cancer. Unlike oncogenes, tumor suppressor genes generally require biallelic inactivation in order to demonstrate a cancerous phenotype. Importantly, the discovery of heritable tumor suppressor gene mutations that lead to familial forms of cancer has revealed great insight into tumor suppressor function. This has clinical screening implications for individuals with a family history of cancer and has led to newer therapies to target cancer cells with loss of specific tumor suppressors.
  • Publisher: Hoboken, NJ, USA: John Wiley & Sons, Inc
  • Language: English
  • Identifier: ISBN: 9781118934692
    ISBN: 1118934695
    EISBN: 1119000823
    EISBN: 9781119000822
    DOI: 10.1002/9781119000822.hfcm005.pub2
    DOI: 10.1002/9781119000822.hfcm005
  • Source: Ebook Central Academic Complete
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