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Impact of Triglyceride Levels Beyond Low-Density Lipoprotein Cholesterol After Acute Coronary Syndrome in the PROVE IT-TIMI 22 Trial

Journal of the American College of Cardiology, 2008-02, Vol.51 (7), p.724-730 [Peer Reviewed Journal]

American College of Cardiology Foundation ;2008 American College of Cardiology Foundation ;2008 INIST-CNRS ;Copyright Elsevier Limited Feb 19, 2008 ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2007.10.038 ;PMID: 18279736 ;CODEN: JACCDI

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Title:
Impact of Triglyceride Levels Beyond Low-Density Lipoprotein Cholesterol After Acute Coronary Syndrome in the PROVE IT-TIMI 22 Trial
Author: Miller, Michael, MD, FACC ; Cannon, Christopher P., MD, FACC ; Murphy, Sabina A., MPH ; Qin, Jie, MS ; Ray, Kausik K., MD, MRCP ; Braunwald, Eugene, MD, MACC
Subjects: Acute Coronary Syndrome - blood ; Acute Coronary Syndrome - drug therapy ; Acute Coronary Syndrome - epidemiology ; Acute coronary syndromes ; Anticholesteremic Agents - therapeutic use ; Atorvastatin Calcium ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Cholesterol ; Cholesterol, LDL - blood ; Confidence intervals ; Coronary Disease - blood ; Coronary Disease - epidemiology ; Coronary heart disease ; Diabetes ; Estimates ; Female ; Heart ; Heart attacks ; Heptanoic Acids - therapeutic use ; Humans ; Hypertension ; Internal Medicine ; Lipids ; Lipoproteins ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - epidemiology ; Myocarditis. Cardiomyopathies ; Obesity ; Population ; Pravastatin - therapeutic use ; Proportional Hazards Models ; Pyrroles - therapeutic use ; Recurrence ; Risk Assessment ; Statins ; Triglycerides ; Triglycerides - blood ; Variables
Is Part Of: Journal of the American College of Cardiology, 2008-02, Vol.51 (7), p.724-730
Description: Impact of Triglyceride Levels Beyond Low-Density Lipoprotein Cholesterol After Acute Coronary Syndrome in the PROVE IT-TIMI 22 Trial Michael Miller, Christopher P. Cannon, Sabina A. Murphy, Jie Qin, Kausik K. Ray, Eugene Braunwald, for the PROVE IT-TIMI Investigators We evaluated the impact of triglycerides (TG) on coronary heart disease (CHD) risk after an acute coronary syndrome (ACS) in the PROVE IT-TIMI (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction) 22 trial. For each 10-mg/dl on-treatment reduction in TG, the incidence of death, myocardial infarction, and recurrent ACS was significantly reduced after adjustment for low-density lipoprotein cholesterol (LDL-C) or non–high-density lipoprotein cholesterol and other covariates. We also observed a significant relationship between the percentage of TG lowering and incidence of CHD events in adjusted analysis. Achieving low TG may be an additional consideration beyond low LDL-C in patients after ACS.
Publisher: New York, NY: Elsevier Inc
Language: English
Identifier: ISSN: 0735-1097
EISSN: 1558-3597
DOI: 10.1016/j.jacc.2007.10.038
PMID: 18279736
CODEN: JACCDI
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

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Impact of Triglyceride Levels Beyond Low-Density Lipoprotein Cholesterol After Acute Coronary Syndrome in the PROVE IT-TIMI 22 Trial

American College of Cardiology Foundation ;2008 American College of Cardiology Foundation ;2008 INIST-CNRS ;Copyright Elsevier Limited Feb 19, 2008 ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2007.10.038 ;PMID: 18279736 ;CODEN: JACCDI

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