skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

P176 Investigating environmental factors associated with cerebral abscesses in patients with pulmonary arteriovenous malformations via an international online questionnaire

Thorax, 2017-12, Vol.72 (Suppl 3), p.A177 [Peer Reviewed Journal]

2017, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;Copyright: 2017 © 2017, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;ISSN: 0040-6376 ;EISSN: 1468-3296 ;DOI: 10.1136/thoraxjnl-2017-210983.318

Full text available

Citations Cited by
  • Title:
    P176 Investigating environmental factors associated with cerebral abscesses in patients with pulmonary arteriovenous malformations via an international online questionnaire
  • Author: Boother, EJ ; von Widekind, SC ; Shovlin, CL
  • Subjects: Questionnaires
  • Is Part Of: Thorax, 2017-12, Vol.72 (Suppl 3), p.A177
  • Description: Introduction and objectivesPatients with pulmonary arteriovenous malformations (PAVMs) are at high risk of cerebral abscess with life-changing morbidity and mortality. These patients often concurrently have hereditary haemorrhagic telangiectasia (HHT). A recent study of patients with PAVMs/HHT at a single institution suggested several environmental associations with cerebral abscess, particularly dental care, higher iron intake, and long-haul flights.1 For example, 4/37 (10.8%) cerebral abscess patients reported their abscess occurred after long-distance travel.MethodsIn order to capture data on wider exposure of this population to such risk factors, an online questionnaire was developed using Survey Monkey. In total, 139 non-biassed questions gathered data online about an individual’s HHT and/or PAVM phenotype, and environmental factors of relevance to cerebral abscess and other study foci in our group. With ethical approval (16/LO/1909), participants were recruited following advertisement through global HHT support networks.ResultsThe survey opened on 31 st May 2017. Within 7 weeks, 449 patients with self-reported HHT had completed the questionnaire. The majority (≥60%) were North Americans, with Europeans constituting the second largest group. 229 (51%) had PAVMs, usually diagnosed in their twenties to fifties. 89/229 (38.9%) had been treated by PAVM embolization and 13 (5.7%) by surgery. 17 (7.42%) had experienced a cerebral abscess and 46 gave a family history of cerebral abscess. Preliminary analysis of long-distance travel data revealed most patients rarely travelled for ≥3 hours. 266 participants reported the number of flights they had taken in their lifetime of durations<4 hours, 4–8 hours and ≥8 hours. In total, an estimated 27,722 hours were flown giving a mean average of 122 hours, i.e., approximately 10 long-distance flights per lifetime.ConclusionsThis survey provides a large dataset from individuals with PAVMs/HHT, captured without a bias toward flight usage as in flight-specific surveys. The data suggest long-distance travel is less common than previously thought for the HHT population, which adds greater weight to the previously published association[1] between long-distance travel and cerebral abscess risk. This approach should enable the development of better tools to predict and reduce the risk of cerebral abscess for these patients.ReferenceBootheret al. Clin Infect Dis2017, Apr 19. doi:10.1093/cid/cix373
  • Publisher: London: BMJ Publishing Group LTD
  • Language: English
  • Identifier: ISSN: 0040-6376
    EISSN: 1468-3296
    DOI: 10.1136/thoraxjnl-2017-210983.318
  • Source: Alma/SFX Local Collection
    ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait