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Cohort profile: Epigenetics in Pregnancy (EPIPREG) - population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes

PloS one, 2021-01, Vol.16 (8), p.e0256158-e0256158 [Peer Reviewed Journal]

2021 Fragoso-Bargas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;info:eu-repo/semantics/openAccess ;2021 Fragoso-Bargas et al 2021 Fragoso-Bargas et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0256158 ;PMID: 34388220

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Title:
Cohort profile: Epigenetics in Pregnancy (EPIPREG) - population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes
Author: Fragoso-Bargas, Nicolas ; Opsahl, Julia O ; Kiryushchenko, Nadezhda ; Böttcher, Yvonne ; Lee-Ødegård, Sindre ; Qvigstad, Elisabeth ; Richardsen, Kåre Rønn ; Waage, Christin W ; Sletner, Line ; Jenum, Anne Karen ; Prasad, Rashmi B ; Groop, Leif C ; Moen, Gunn-Helen ; Birkeland, Kåre I ; Sommer, Christine
Lim, Lee-Ling
Subjects: Adult ; Anthropometry - methods ; Aquatic birds ; Asians - genetics ; Basic Medicine ; Bioelectricity ; Biology and life sciences ; Bisulfite ; Blood ; Child Health ; Cohort Studies ; Cord blood ; CpG islands ; Deoxyribonucleic acid ; Diabetes mellitus ; DNA ; DNA Methylation ; Epigenetics ; Epigenome ; Exercise ; Exercise - statistics & numerical data ; Female ; Genotypes ; Humans ; Insulin resistance ; Leukocytes ; Leukocytes, Mononuclear - cytology ; Leukocytes, Mononuclear - metabolism ; Medical and Health Sciences ; Medical Genetics ; Medicin och hälsovetenskap ; Medicine and Health Sciences ; Medicinsk genetik ; Medicinska och farmaceutiska grundvetenskaper ; Minority & ethnic groups ; Missing data ; Mothers ; Norway ; Offspring ; People and Places ; Peripheral blood ; Physical activity ; Physical Sciences ; Placenta ; Pregnancy ; Pregnancy - genetics ; Preventive medicine ; Risk reduction ; Surveys and Questionnaires ; Whites - genetics ; Womens health
Is Part Of: PloS one, 2021-01, Vol.16 (8), p.e0256158-e0256158
Description: Pregnancy is a valuable model to study the association between DNA methylation and several cardiometabolic traits, due to its direct potential to influence mother's and child's health. Epigenetics in Pregnancy (EPIPREG) is a population-based sample with the aim to study associations between DNA-methylation in pregnancy and cardiometabolic traits in South Asian and European pregnant women and their offspring. This cohort profile paper aims to present our sample with genetic and epigenetic data and invite researchers with similar cohorts to collaborative projects, such as replication of ours or their results and meta-analysis. In EPIPREG we have quantified epigenome-wide DNA methylation in maternal peripheral blood leukocytes in gestational week 28±1 in Europeans (n = 312) and South Asians (n = 168) that participated in the population-based cohort STORK Groruddalen, in Norway. DNA methylation was measured with Infinium MethylationEPIC BeadChip (850k sites), with technical validation of four CpG sites using bisulphite pyrosequencing in a subset (n = 30). The sample is well characterized with few missing data on e.g. genotype, universal screening for gestational diabetes, objectively measured physical activity, bioelectrical impedance, anthropometrics, biochemical measurements, and a biobank with maternal serum and plasma, urine, placenta tissue. In the offspring, we have repeated ultrasounds during pregnancy, cord blood, and anthropometrics up to 4 years of age. We have quantified DNA methylation in peripheral blood leukocytes in nearly all eligible women from the STORK Groruddalen study, to minimize the risk of selection bias. Genetic principal components distinctly separated Europeans and South Asian women, which fully corresponded with the self-reported ethnicity. Technical validation of 4 CpG sites from the methylation bead chip showed good agreement with bisulfite pyrosequencing. We plan to study associations between DNA methylation and cardiometabolic traits and outcomes.
Publisher: United States: Public Library of Science
Language: English;Norwegian
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0256158
PMID: 34388220
Source: GFMER Free Medical Journals
MEDLINE
NORA Norwegian Open Research Archives
PubMed Central
SWEPUB Freely available online
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

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Cohort profile: Epigenetics in Pregnancy (EPIPREG) - population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes

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