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Association of depression and diabetes complications and mortality: a population-based cohort study

Epidemiology and psychiatric sciences, 2020-01, Vol.29, p.e96, Article e96 [Peer Reviewed Journal]

Copyright Cambridge University Press 2020 ;The Author(s) 2020 2020 The Author(s) ;ISSN: 2045-7960 ;EISSN: 2045-7979 ;DOI: 10.1017/S2045796020000049 ;PMID: 31992379

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  • Title:
    Association of depression and diabetes complications and mortality: a population-based cohort study
  • Author: Wu, C-S ; Hsu, L-Y ; Wang, S-H
  • Subjects: Accuracy ; Acute coronary syndromes ; Adult ; Aged ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - epidemiology ; Codes ; Cohort Studies ; Depression - complications ; Depression - mortality ; Depression - psychology ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - mortality ; Diabetic retinopathy ; Female ; Follow-Up Studies ; Foot diseases ; Humans ; Incidence ; Kidney diseases ; Male ; Mental depression ; Middle Aged ; Mortality ; Original ; Patients ; Population ; Risk Factors ; Stroke ; Studies ; Taiwan - epidemiology
  • Is Part Of: Epidemiology and psychiatric sciences, 2020-01, Vol.29, p.e96, Article e96
  • Description: Several studies suggested that depression might worsen the clinical outcome of diabetes mellitus; however, such association was confounded by duration of illness and baseline complications. This study aimed to assess whether depression increases the risk of diabetes complications and mortality among incident patients with diabetes. This was a population-based matched cohort study using Taiwan's National Health Insurance Research Database. A total of 38 537 incident patients with diabetes who had depressive disorders and 154 148 incident diabetes patients without depression who were matched by age, sex and cohort entry year were randomly selected. The study endpoint was the development of macrovascular and microvascular complications, all-cause mortality and cause-specific mortality. Among participants, the mean (±SD) age was 52.61 (±12.45) years, and 39.63% were male. The average duration of follow-up for mortality was 5.5 years, ranging from 0 to 14 years. The adjusted hazard ratios were 1.35 (95% confidence interval [CI], 1.32-1.37) for macrovascular complications and 1.08 (95% CI, 1.04-1.12) for all-cause mortality. However, there was no association of depression with microvascular complications, mortality due to cardiovascular diseases or mortality due to diabetes mellitus. The effect of depression on diabetes complications and mortality was more prominent among young adults than among middle-aged and older adults. Depression was associated with macrovascular complications and all-cause mortality in our patient cohort. However, the magnitude of association was less than that in previous studies. Further research should focus on the benefits and risks of treatment for depression on diabetes outcome.
  • Publisher: England: Cambridge University Press
  • Language: English;Italian
  • Identifier: ISSN: 2045-7960
    EISSN: 2045-7979
    DOI: 10.1017/S2045796020000049
    PMID: 31992379
  • Source: ProQuest One Psychology
    Journals@Ovid Open Access Journal Collection Rolling
    AUTh Library subscriptions: ProQuest Central
    MEDLINE
    PubMed Central
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