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Sleep duration and risk of all-cause mortality: a systematic review and meta-analysis

Epidemiology and psychiatric sciences, 2019-10, Vol.28 (5), p.578-588 [Peer Reviewed Journal]

Copyright © Cambridge University Press 2018 ;Cambridge University Press 2018 2018 Cambridge University Press ;ISSN: 2045-7960 ;EISSN: 2045-7979 ;DOI: 10.1017/S2045796018000379 ;PMID: 30058510

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  • Title:
    Sleep duration and risk of all-cause mortality: a systematic review and meta-analysis
  • Author: García-Perdomo, H. A. ; Zapata-Copete, J. ; Rojas-Cerón, C. A.
  • Subjects: Adult ; Aged ; Aged, 80 and over ; Bias ; Cardiovascular disease ; Female ; Humans ; Male ; Meta-analysis ; Middle Aged ; Mortality ; Neurological diseases ; Original ; Original Articles ; Qualitative analysis ; Quantitative analysis ; Risk ; Sleep ; Sleep - physiology ; Sleep deprivation ; Sleep Wake Disorders - mortality ; Sleep Wake Disorders - physiopathology ; Systematic review ; Time Factors
  • Is Part Of: Epidemiology and psychiatric sciences, 2019-10, Vol.28 (5), p.578-588
  • Description: To determine the association between the sleep duration and the risk of all-cause mortality in adults. A search strategy was conducted in the MEDLINE, CENTRAL, EMBASE and LILACS databases. Searches were also conducted in other databases and unpublished literature. Cohort studies were included without language, time or setting restrictions. The risk of bias was evaluated with a modified Cochrane Collaboration's tool. An analysis of random effects was conducted. The primary outcome was all-cause mortality. The measure of the effect was the risk difference (RD) with a 95% confidence interval (CI). The planned comparisons were 7-9 h of sleep v. <7 h and the same reference v. >9 h. Thirty-nine studies were included in our qualitative analysis, regarding the quantitative analysis, 19 studies were included in <7 v. 7-9 h analysis, and 18 studies in the >9 v. 7-9 h. A low risk of bias was shown for most of the study items. The overall RD for all-cause mortality was 0.09 (95% CI 0.07-0.11) favouring the >9 h group compared with our reference. In contrast, no differences were found between the <7 h and the reference sleep duration groups (RD 0.00, 95% CI 0.00-0.01). We found a probable association of long sleep duration and higher mortality; however, it could reflect an underlying systemic or neurological disease that cause sleep fragmentation, deterioration in quality and micro-awakenings.
  • Publisher: Cambridge, UK: Cambridge University Press
  • Language: English;Italian
  • Identifier: ISSN: 2045-7960
    EISSN: 2045-7979
    DOI: 10.1017/S2045796018000379
    PMID: 30058510
  • Source: ProQuest One Psychology
    Journals@Ovid Open Access Journal Collection Rolling
    MEDLINE
    PubMed Central
    ProQuest Central
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