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Inflammation and atherosclerosis – last piece of the puzzle has fallen into place

Läkartidningen, 2017-10, Vol.114 [Peer Reviewed Journal]

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Title:
Inflammation and atherosclerosis – last piece of the puzzle has fallen into place
Author: Jonasson, Lena ; Hansson, Göran
Subjects: Anti-Inflammatory Agents - administration & dosage ; Antibodies, Monoclonal - administration & dosage ; Atherosclerosis - drug therapy ; Atherosclerosis - pathology ; Cardiovascular Diseases - prevention & control ; Cholesterol, LDL - blood ; Humans ; Inflammation - drug therapy ; Inflammation - pathology ; Interleukin-1beta - antagonists & inhibitors ; Medicin och hälsovetenskap ; Risk
Is Part Of: Läkartidningen, 2017-10, Vol.114
Description: Inflammation and atherosclerosis - last piece of the puzzle has fallen into place Inflammation is a major component of atherosclerotic lesions and inflammatory biomarkers can be used to predict cardiovascular disease. Still, it has been unclear whether inflammation is a driving force in atherosclerosis, or merely an epiphenomenon. The recently published results of the CANTOS trial shows that treatment with canacinumab, a monoclonal antibody to the proinflammatory cytokine interleukin-1β, led to a significantly lower rate of recurrent cardiovascular events, compared to placebo. Thus, it establishes beyond doubt that inflammation is a treatable pathogenetic mechanism in atherosclerosis.
Publisher: Sweden
Language: Swedish;English
Identifier: ISSN: 1652-7518
EISSN: 1652-7518
PMID: 29292899
Source: MEDLINE
Alma/SFX Local Collection

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