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Diabetes-induced male infertility: potential mechanisms and treatment options

Molecular medicine (Cambridge, Mass.), 2024-01, Vol.30 (1), p.11-11, Article 11 [Peer Reviewed Journal]

2023. The Author(s). ;The Author(s) 2023 ;ISSN: 1528-3658 ;ISSN: 1076-1551 ;EISSN: 1528-3658 ;DOI: 10.1186/s10020-023-00771-x ;PMID: 38225568

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  • Title:
    Diabetes-induced male infertility: potential mechanisms and treatment options
  • Author: Huang, Runchun ; Chen, Jiawang ; Guo, Buyu ; Jiang, Chenjun ; Sun, Weiming
  • Subjects: Chronic inflammation ; Diabetes ; Diabetes Mellitus ; Endocrine disorders ; Female ; Humans ; Hyperglycemia ; Infertility, Male - etiology ; Infertility, Male - therapy ; Leydig Cells ; Male ; Male infertility ; Oxidative stress ; Review
  • Is Part Of: Molecular medicine (Cambridge, Mass.), 2024-01, Vol.30 (1), p.11-11, Article 11
  • Description: Male infertility is a physiological phenomenon in which a man is unable to impregnate a fertile woman during a 12-month period of continuous, unprotected sexual intercourse. A growing body of clinical and epidemiological evidence indicates that the increasing incidence of male reproductive problems, especially infertility, shows a very similar trend to the incidence of diabetes within the same age range. In addition, a large number of previous in vivo and in vitro experiments have also suggested that the complex pathophysiological changes caused by diabetes may induce male infertility in multiple aspects, including hypothalamic-pituitary-gonadal axis dysfunction, spermatogenesis and maturation disorders, testicular interstitial cell damage erectile dysfunction. Based on the above related mechanisms, a large number of studies have focused on the potential therapeutic association between diabetes progression and infertility in patients with diabetes and infertility, providing important clues for the treatment of this population. In this paper, we summarized the research results of the effects of diabetes on male reproductive function in recent 5 years, elaborated the potential pathophysiological mechanisms of male infertility induced by diabetes, and reviewed and prospected the therapeutic measures.
  • Publisher: England: BioMed Central
  • Language: English
  • Identifier: ISSN: 1528-3658
    ISSN: 1076-1551
    EISSN: 1528-3658
    DOI: 10.1186/s10020-023-00771-x
    PMID: 38225568
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    AUTh Library subscriptions: ProQuest Central
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