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Race, Genetic Ancestry, and Estimating Kidney Function in CKD

The New England journal of medicine, 2021-11, Vol.385 (19), p.1750-1760 [Peer Reviewed Journal]

Copyright © 2021 Massachusetts Medical Society. All rights reserved. ;Copyright © 2021 Massachusetts Medical Society. ;COPYRIGHT 2021 Massachusetts Medical Society ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa2103753 ;PMID: 34554660

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Title:
Race, Genetic Ancestry, and Estimating Kidney Function in CKD
Author: Hsu, Chi-yuan ; Yang, Wei ; Parikh, Rishi V ; Anderson, Amanda H ; Chen, Teresa K ; Cohen, Debbie L ; He, Jiang ; Mohanty, Madhumita J ; Lash, James P ; Mills, Katherine T ; Muiru, Anthony N ; Parsa, Afshin ; Saunders, Milda R ; Shafi, Tariq ; Townsend, Raymond R ; Waikar, Sushrut S ; Wang, Jianqiao ; Wolf, Myles ; Tan, Thida C ; Feldman, Harold I ; Go, Alan S
Subjects: Adult ; Age ; Aged ; Algorithms ; Analysis and chemistry ; Blacks ; Blood ; Chronic Kidney Disease ; Chronic kidney failure ; Clinical Practice ; Creatinine ; Creatinine - blood ; Cross-Sectional Studies ; Cystatin ; Cystatin C ; Cystatin C - blood ; Datasets ; Demographic aspects ; Diabetes ; Diabetes mellitus ; Diagnosis ; Ethnicity ; Female ; Genetic susceptibility ; Genetics ; Genetics General ; Glomerular Filtration Rate ; Health aspects ; Health Policy ; Hospitalist ; Humans ; Kidney diseases ; Kidneys ; Male ; Middle Aged ; Minority & ethnic groups ; Nephrology ; Nephrology General ; Physiological aspects ; Primary Care ; Public Health ; Race relations ; Racial Groups ; Regression analysis ; Renal Insufficiency, Chronic - ethnology ; Renal Insufficiency, Chronic - genetics ; Renal Insufficiency, Chronic - physiopathology ; United States
Is Part Of: The New England journal of medicine, 2021-11, Vol.385 (19), p.1750-1760
Description: The use of race in equations that estimate the glomerular filtration rate is problematic. In this study, the use of the serum creatinine level to estimate the GFR without race (or genetic ancestry) introduced systematic misclassification. Estimating GFR with cystatin C generated similar results but eliminated negative consequences of race-based approaches.
Publisher: United States: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa2103753
PMID: 34554660
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Race, Genetic Ancestry, and Estimating Kidney Function in CKD

Copyright © 2021 Massachusetts Medical Society. All rights reserved. ;Copyright © 2021 Massachusetts Medical Society. ;COPYRIGHT 2021 Massachusetts Medical Society ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa2103753 ;PMID: 34554660

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