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The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease

Nature reviews. Nephrology, 2018-07, Vol.14 (7), p.442-456 [Peer Reviewed Journal]

COPYRIGHT 2018 Nature Publishing Group ;COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Jul 2018 ;ISSN: 1759-5061 ;EISSN: 1759-507X ;DOI: 10.1038/s41581-018-0018-2 ;PMID: 29760448

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Title:
The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease
Author: Yang, Tao ; Richards, Elaine M ; Pepine, Carl J ; Raizada, Mohan K
Subjects: Animals ; Brain - physiopathology ; Chronic kidney failure ; Clinical trials ; Complications and side effects ; Enteroendocrine Cells - metabolism ; Epigenesis, Genetic ; Fatty Acids, Volatile - metabolism ; Gastrointestinal Microbiome - physiology ; Gastrointestinal Tract - physiopathology ; Homeostasis ; Humans ; Hypertension ; Hypertension - etiology ; Hypertension - physiopathology ; Kidney - physiopathology ; Kidney diseases ; Medical research ; Metabolites ; Microbiota ; Microbiota (Symbiotic organisms) ; Renal Insufficiency, Chronic - etiology ; Renal Insufficiency, Chronic - physiopathology ; Renal Insufficiency, Chronic - therapy ; Risk factors ; Sympathetic Nervous System - physiopathology
Is Part Of: Nature reviews. Nephrology, 2018-07, Vol.14 (7), p.442-456
Description: Crosstalk between the gut microbiota and the host has attracted considerable attention owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly associated with hypertension and is characterized by immune dysregulation, metabolic disorder and sympathetic activation, which are all linked to gut dysbiosis and altered host-microbiota crosstalk. In this Review, we discuss the complex interplay between the brain, the gut, the microbiota and the kidney in CKD and hypertension and explain our brain-gut-kidney axis hypothesis for the pathogenesis of these diseases. Consideration of the role of the brain-gut-kidney axis in the maintenance of normal homeostasis and of dysregulation of this axis in CKD and hypertension could lead to the identification of novel therapeutic targets. In addition, the discovery of unique microbial communities and their associated metabolites and the elucidation of brain-gut-kidney signalling are likely to fill fundamental knowledge gaps leading to innovative research, clinical trials and treatments for CKD and hypertension.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1759-5061
EISSN: 1759-507X
DOI: 10.1038/s41581-018-0018-2
PMID: 29760448
Source: AUTh Library subscriptions: ProQuest Central
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The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease

COPYRIGHT 2018 Nature Publishing Group ;COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Jul 2018 ;ISSN: 1759-5061 ;EISSN: 1759-507X ;DOI: 10.1038/s41581-018-0018-2 ;PMID: 29760448

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