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The pathogenic role of coronary microvascular dysfunction in the setting of other cardiac or systemic conditions

Cardiovascular research, 2020-03, Vol.116 (4), p.817-828 [Peer Reviewed Journal]

The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. 2020 ;Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com. ;ISSN: 0008-6363 ;EISSN: 1755-3245 ;DOI: 10.1093/cvr/cvaa009 ;PMID: 31977015

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  • Title:
    The pathogenic role of coronary microvascular dysfunction in the setting of other cardiac or systemic conditions
  • Author: Konst, Regina E ; Guzik, Tomasz J ; Kaski, Juan-Carlos ; Maas, Angela H E M ; Elias-Smale, Suzette E
  • Subjects: Editor's Choice ; Spotlight Review
  • Is Part Of: Cardiovascular research, 2020-03, Vol.116 (4), p.817-828
  • Description: Abstract Coronary microvascular dysfunction (CMD) plays a pathogenic role in cardiac and systemic conditions other than microvascular angina. In this review, we provide an overview of the pathogenic role of CMD in the setting of diabetes mellitus, obesity, hypertensive pregnancy disorders, chronic inflammatory and autoimmune rheumatic disorders, chronic kidney disease, hypertrophic cardiomyopathy, and aortic valve stenosis. In these various conditions, CMD results from different structural, functional, and/or dynamic alterations in the coronary microcirculation associated with the primary disease process. CMD is often detectable very early in the course of the primary disease, before clinical symptoms or signs of myocardial ischaemia are present, and it portrays an increased risk for cardiovascular events. Graphical Abstract Graphical Abstract
  • Publisher: England: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0008-6363
    EISSN: 1755-3245
    DOI: 10.1093/cvr/cvaa009
    PMID: 31977015
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    Oxford University Press Open Access
    Alma/SFX Local Collection
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