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Distinct Oscillatory Frequencies Underlie Excitability of Human Occipital and Parietal Cortex

The Journal of neuroscience, 2017-03, Vol.37 (11), p.2824-2833 [Peer Reviewed Journal]

Copyright © 2017 the authors 0270-6474/17/372824-10$15.00/0. ;Copyright © 2017 the authors 0270-6474/17/372824-10$15.00/0 2017 ;ISSN: 0270-6474 ;ISSN: 1529-2401 ;EISSN: 1529-2401 ;DOI: 10.1523/jneurosci.3413-16.2017 ;PMID: 28179556

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  • Title:
    Distinct Oscillatory Frequencies Underlie Excitability of Human Occipital and Parietal Cortex
  • Author: Samaha, Jason ; Gosseries, Olivia ; Postle, Bradley R
  • Subjects: Action Potentials - physiology ; Adult ; Alpha Rhythm - physiology ; Biological Clocks - physiology ; cortical excitability ; Cortical Excitability - physiology ; Female ; Humans ; Male ; Nerve Net - physiology ; Neurosciences & behavior ; Neurosciences & comportement ; occipital ; Occipital Lobe - physiology ; oscillations ; parietal ; Parietal Lobe - physiology ; phosphenes ; Phosphenes - physiology ; Sciences sociales & comportementales, psychologie ; Social & behavioral sciences, psychology ; Transcranial Magnetic Stimulation - methods ; visual perception ; Young Adult
  • Is Part Of: The Journal of neuroscience, 2017-03, Vol.37 (11), p.2824-2833
  • Description: Transcranial magnetic stimulation (TMS) of human occipital and posterior parietal cortex can give rise to visual sensations called phosphenes. We used near-threshold TMS with concurrent EEG recordings to measure how oscillatory brain dynamics covary, on single trials, with the perception of phosphenes after occipital and parietal TMS. Prestimulus power and phase, predominantly in the alpha band (8-13 Hz), predicted occipital TMS phosphenes, whereas higher-frequency beta-band (13-20 Hz) power (but not phase) predicted parietal TMS phosphenes. TMS-evoked responses related to phosphene perception were similar across stimulation sites and were characterized by an early (200 ms) posterior negativity and a later (>300 ms) parietal positivity in the time domain and an increase in low-frequency (∼5-7 Hz) power followed by a broadband decrease in alpha/beta power in the time-frequency domain. These correlates of phosphene perception closely resemble known electrophysiological correlates of conscious perception of near-threshold visual stimuli. The regionally differential pattern of prestimulus predictors of phosphene perception suggests that distinct frequencies may reflect cortical excitability in occipital versus posterior parietal cortex, calling into question the broader assumption that the alpha rhythm may serve as a general index of cortical excitability. Alpha-band oscillations are thought to reflect cortical excitability and are therefore ascribed an important role in gating information transmission across cortex. We probed cortical excitability directly in human occipital and parietal cortex and observed that, whereas alpha-band dynamics indeed reflect excitability of occipital areas, beta-band activity was most predictive of parietal cortex excitability. Differences in the state of cortical excitability predicted perceptual outcomes (phosphenes), which were manifest in both early and late patterns of evoked activity, revealing the time course of phosphene perception. Our findings prompt revision of the notion that alpha activity reflects excitability across all of cortex and suggest instead that excitability in different regions is reflected in distinct frequency bands.
  • Publisher: United States: Society for Neuroscience
  • Language: English
  • Identifier: ISSN: 0270-6474
    ISSN: 1529-2401
    EISSN: 1529-2401
    DOI: 10.1523/jneurosci.3413-16.2017
    PMID: 28179556
  • Source: Open Access: PubMed Central
    Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    Alma/SFX Local Collection
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