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Risk Factors for Retinopathy and DME in Type 2 Diabetes-Results from the German/Austrian DPV Database

PloS one, 2015-07, Vol.10 (7), p.e0132492-e0132492 [Peer Reviewed Journal]

2015 Hammes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2015 Hammes et al 2015 Hammes et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0132492 ;PMID: 26177037

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Title:
Risk Factors for Retinopathy and DME in Type 2 Diabetes-Results from the German/Austrian DPV Database
Author: Hammes, Hans-Peter ; Welp, Reinhard ; Kempe, Hans-Peter ; Wagner, Christian ; Siegel, Erhard ; Holl, Reinhard W
Strauß, Olaf
Subjects: Age ; Aged ; Austria ; Blood pressure ; Body mass ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetic retinopathy ; Diabetic Retinopathy - blood ; Diabetic Retinopathy - epidemiology ; Diabetic Retinopathy - etiology ; Disease Progression ; Edema ; Female ; Gastrointestinal surgery ; Germany ; Glucose ; Glycated Hemoglobin A - metabolism ; Health risk assessment ; Health risks ; Hemoglobin ; Humans ; Hypertension ; Internal medicine ; Macular Edema - blood ; Macular Edema - epidemiology ; Macular Edema - etiology ; Male ; Medical treatment ; Metabolic syndrome ; Obesity ; Patients ; Prevalence ; Regression analysis ; Retinopathy ; Risk analysis ; Risk Factors ; Severity of Illness Index ; Stratigraphy ; Survival analysis
Is Part Of: PloS one, 2015-07, Vol.10 (7), p.e0132492-e0132492
Description: To assess the prevalence and risk factors for early and severe diabetic retinopathy and macular edema in a large cohort of patients with type 2 diabetes Retinopathy grading (any retinopathy, severe retinopathy, diabetic macular edema) and risk factors of 64784 were prospectively recorded between January 2000 and March 2013 and analyzed by Kaplan-Meier analysis and logistic regression. Retinopathy was present in 20.12% of subjects, maculopathy was found in 0.77%. HbA1c > 8%, microalbuminuria, hypertension, BMI > 35 kg/m2 and male sex were significantly associated with any retinopathy, while HbA1c and micro- and macroalbuminuria were the strongest risk predictors for severe retinopathy. Presence of macroalbuminuria increased the risk for DME by 177%. Retinopathy remains a significant clinical problem in patients with type 2 diabetes. Metabolic control and blood pressure are relevant factors amenable to treatment. Concomitant kidney disease identifies high risk patients and should be emphasized in interdisciplinary communication.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0132492
PMID: 26177037
Source: Freely Accessible Journals
PubMed (Medline)
AUTh Library subscriptions: ProQuest Central
MEDLINE
Public Library of Science
DOAJ Directory of Open Access Journals

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Risk Factors for Retinopathy and DME in Type 2 Diabetes-Results from the German/Austrian DPV Database

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