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Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells

The Journal of experimental medicine, 2007-02, Vol.204 (2), p.253-258 [Peer Reviewed Journal]

Copyright © 2007, The Rockefeller University Press ;ISSN: 0022-1007 ;EISSN: 1540-9538 ;DOI: 10.1084/jem.20062211 ;PMID: 17242164

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Title:
Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
Author: Allakhverdi, Zoulfia ; Comeau, Michael R ; Jessup, Heidi K ; Yoon, Bo-Rin Park ; Brewer, Avery ; Chartier, Suzanne ; Paquette, Nicole ; Ziegler, Steven F ; Sarfati, Marika ; Delespesse, Guy
Subjects: Analysis of Variance ; Brief Definitive Reports ; Cytokines - metabolism ; DNA, Complementary - genetics ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells - metabolism ; Humans ; Hypersensitivity - etiology ; Immunity, Innate - immunology ; Mast Cells - immunology ; Polymerase Chain Reaction ; Receptors, Cytokine - metabolism
Is Part Of: The Journal of experimental medicine, 2007-02, Vol.204 (2), p.253-258
Description: Compelling evidence suggests that the epithelial cell-derived cytokine thymic stromal lymphopoietin (TSLP) may initiate asthma or atopic dermatitis through a dendritic cell-mediated T helper (Th)2 response. Here, we describe how TSLP might initiate and aggravate allergic inflammation in the absence of T lymphocytes and immunoglobulin E antibodies via the innate immune system. We show that TSLP, synergistically with interleukin 1 and tumor necrosis factor, stimulates the production of high levels of Th2 cytokines by human mast cells (MCs). We next report that TSLP is released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines. Direct epithelial cell-mediated, TSLP-dependent activation of MCs may play a central role in "intrinsic" forms of atopic diseases and explain the aggravating role of infection and scratching in these diseases.
Publisher: United States: The Rockefeller University Press
Language: English
Identifier: ISSN: 0022-1007
EISSN: 1540-9538
DOI: 10.1084/jem.20062211
PMID: 17242164
Source: PubMed
Geneva Foundation Free Medical Journals at publisher websites
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Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells

Copyright © 2007, The Rockefeller University Press ;ISSN: 0022-1007 ;EISSN: 1540-9538 ;DOI: 10.1084/jem.20062211 ;PMID: 17242164

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