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Fasting glucose levels within the high normal range predict cardiovascular outcome

The American heart journal, 2012-07, Vol.164 (1), p.111-116 [Peer Reviewed Journal]

Mosby, Inc. ;2012 Mosby, Inc. ;2015 INIST-CNRS ;Copyright © 2012 Mosby, Inc. All rights reserved. ;Copyright Elsevier Limited Jul 2012 ;ISSN: 0002-8703 ;EISSN: 1097-6744 ;DOI: 10.1016/j.ahj.2012.03.023 ;PMID: 22795290 ;CODEN: AHJOA2

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Title:
Fasting glucose levels within the high normal range predict cardiovascular outcome
Author: Shaye, Kivity, MD ; Amir, Tirosh, MD, PhD ; Shlomo, Segev, MD ; Yechezkel, Sidi, MD
Subjects: Acute coronary syndromes ; Adult ; Age ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Blood Glucose - analysis ; Body mass index ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Cholesterol ; Diabetes ; Diabetes Mellitus - blood ; Diabetic Angiopathies - epidemiology ; Diabetic Cardiomyopathies - epidemiology ; Family medical history ; Fasting ; Female ; Glucose ; Heart attacks ; Humans ; Male ; Medical imaging ; Medical records ; Medical sciences ; Medical screening ; Middle Aged ; Mortality ; Population ; Reference Values ; Risk Assessment ; Risk factors ; Womens health
Is Part Of: The American heart journal, 2012-07, Vol.164 (1), p.111-116
Description: Background Diabetes mellitus and impaired glucose metabolism are associated with increased risk for cardiovascular disease (CVD). However, it is still not clear whether glucose levels can predict CVD risk among patients without diabetes. The primary aim of this study is to assess whether normoglycemic fasting plasma glucose (FPG) is associated with increased risk of CVD outcomes in healthy patients. Methods We obtained blood measurements, data from physical examination, and medical and lifestyle information from 10,913 men and women who were evaluated in the Institute for Preventive Medicine of Sheba Medical Center. Enrolled were participants with FPG < 100 mg/dL as well as 100 to 125 mg/dL, who were free of diagnosis of CVD. The participants were actively screened for coronary disease using a stress test. Primary end points were coronary heart disease or self-reported cerebral vascular disease. Results A total of 1,119 incident cases of CVD occurred during a mean follow-up of 4.3 years. Subjects with fasting glucose levels in the high normal range (95-99 mg/dL) had an increased CVD risk when compared with levels < 80 mg/dL, (HR 1.53;CI 95% [1.22-1.91], P < .001). A multivariate model, adjusted for age, sex, family history of CVD, blood pressure, body mass index, smoking status, pharmacologic treatment, serum triglycerides, and high-density lipoprotein and low-density lipoprotein cholesterol levels, revealed an independent increased risk of CVD with rising FPG levels in the normal range. Conclusion Elevated CVD risk is strongly and independently associated with glucose levels within the normoglycemic range. Fasting plasma glucose may help in identifying apparently healthy persons with early metabolic abnormalities who are at increased risk for CVD before progression to prediabetes and overt diabetes mellitus.
Publisher: New York, NY: Mosby, Inc
Language: English
Identifier: ISSN: 0002-8703
EISSN: 1097-6744
DOI: 10.1016/j.ahj.2012.03.023
PMID: 22795290
CODEN: AHJOA2
Source: MEDLINE
ProQuest Central

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Fasting glucose levels within the high normal range predict cardiovascular outcome

Mosby, Inc. ;2012 Mosby, Inc. ;2015 INIST-CNRS ;Copyright © 2012 Mosby, Inc. All rights reserved. ;Copyright Elsevier Limited Jul 2012 ;ISSN: 0002-8703 ;EISSN: 1097-6744 ;DOI: 10.1016/j.ahj.2012.03.023 ;PMID: 22795290 ;CODEN: AHJOA2

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