Language:

Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease

The American heart journal, 2012-05, Vol.163 (5), p.844-850.e1 [Peer Reviewed Journal]

Mosby, Inc. ;2012 Mosby, Inc. ;2015 INIST-CNRS ;Copyright © 2012 Mosby, Inc. All rights reserved. ;Copyright Elsevier Limited May 2012 ;ISSN: 0002-8703 ;EISSN: 1097-6744 ;DOI: 10.1016/j.ahj.2012.02.005 ;PMID: 22607863 ;CODEN: AHJOA2

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease
Author: Shah, Svati H., MD, MHS ; Sun, Jie-Lena, MS ; Stevens, Robert D., PhD ; Bain, James R., PhD ; Muehlbauer, Michael J., PhD ; Pieper, Karen S., MS ; Haynes, Carol, BS ; Hauser, Elizabeth R., PhD ; Kraus, William E., MD ; Granger, Christopher B., MD ; Newgard, Christopher B., PhD ; Califf, Robert M., MD ; Newby, L. Kristin, MD, MHS
Subjects: Adult ; Age Distribution ; Analysis of Variance ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Blood Chemical Analysis ; Cardiac Catheterization - methods ; Cardiac Catheterization - statistics & numerical data ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - metabolism ; Cohort Studies ; Confidence Intervals ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - metabolism ; Coronary heart disease ; Female ; Heart ; Heart attacks ; Humans ; Lipids - blood ; Male ; Medical sciences ; Metabolites ; Metabolomics - methods ; Middle Aged ; Mortality ; Multivariate Analysis ; Predictive Value of Tests ; Prevalence ; Prognosis ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Sex Distribution ; Stroke Volume ; Survival Analysis
Is Part Of: The American heart journal, 2012-05, Vol.163 (5), p.844-850.e1
Description: Background Cardiovascular risk models remain incomplete. Small-molecule metabolites may reflect underlying disease and, as such, serve as novel biomarkers of cardiovascular risk. Methods We studied 2,023 consecutive patients undergoing cardiac catheterization. Mass spectrometry profiling of 69 metabolites and lipid assessments were performed in fasting plasma. Principal component analysis reduced metabolites to a smaller number of uncorrelated factors. Independent relationships between factors and time-to-clinical events were assessed using Cox modeling. Clinical and metabolomic models were compared using log-likelihood and reclassification analyses. Results At median follow-up of 3.1 years, there were 232 deaths and 294 death/myocardial infarction (MI) events. Five of 13 metabolite factors were independently associated with mortality: factor 1 (medium-chain acylcarnitines: hazard ratio [HR] 1.12 [95% CI, 1.04-1.21], P = .005), factor 2 (short-chain dicarboxylacylcarnitines: HR 1.17 [1.05-1.31], P = .005), factor 3 (long-chain dicarboxylacylcarnitines: HR 1.14 [1.05-1.25], P = .002); factor 6 (branched-chain amino acids: HR 0.86 [0.75-0.99], P = .03), and factor 12 (fatty acids: HR 1.19 [1.06-1.35], P = .004). Three factors independently predicted death/MI: factor 2 (HR 1.11 [1.01-1.23], P = .04), factor 3 (HR 1.13 [1.04-1.22], P = .005), and factor 12 (HR 1.18 [1.05-1.32], P = .004). For mortality, 27% of intermediate-risk patients were correctly reclassified (net reclassification improvement 8.8%, integrated discrimination index 0.017); for death/MI model, 11% were correctly reclassified (net reclassification improvement 3.9%, integrated discrimination index 0.012). Conclusions Metabolic profiles predict cardiovascular events independently of standard predictors.
Publisher: New York, NY: Elsevier Inc
Language: English
Identifier: ISSN: 0002-8703
EISSN: 1097-6744
DOI: 10.1016/j.ahj.2012.02.005
PMID: 22607863
CODEN: AHJOA2
Source: AUTh Library subscriptions: ProQuest Central
MEDLINE

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease

Mosby, Inc. ;2012 Mosby, Inc. ;2015 INIST-CNRS ;Copyright © 2012 Mosby, Inc. All rights reserved. ;Copyright Elsevier Limited May 2012 ;ISSN: 0002-8703 ;EISSN: 1097-6744 ;DOI: 10.1016/j.ahj.2012.02.005 ;PMID: 22607863 ;CODEN: AHJOA2

Searching Remote Databases, Please Wait