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0.2-Hz repetitive transcranial magnetic stimulation has no add-on effects as compared to a realistic sham stimulation in Parkinson's disease

Movement disorders, 2003-04, Vol.18 (4), p.382-388 [Peer Reviewed Journal]

Copyright © 2003 Movement Disorders Society ;2003 INIST-CNRS ;Copyright 2002 Movement Disorder Society ;ISSN: 0885-3185 ;EISSN: 1531-8257 ;DOI: 10.1002/mds.10370 ;PMID: 12671943

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Title:
0.2-Hz repetitive transcranial magnetic stimulation has no add-on effects as compared to a realistic sham stimulation in Parkinson's disease
Author: Okabe, Shingo ; Ugawa, Yoshikazu ; Kanazawa, Ichiro
Subjects: Aged ; Antiparkinson Agents - administration & dosage ; Biological and medical sciences ; Combined Modality Therapy ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Double-Blind Method ; Electric Stimulation Therapy - methods ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Motor Cortex - physiopathology ; Neurology ; Occipital Lobe - physiopathology ; Parkinson Disease - diagnosis ; Parkinson Disease - physiopathology ; Parkinson Disease - therapy ; Parkinson's disease ; placebo effect ; repetitive transcranial magnetic stimulation (rTMS) ; sham stimulation ; Transcranial Magnetic Stimulation - therapeutic use ; treatment ; Treatment Outcome
Is Part Of: Movement disorders, 2003-04, Vol.18 (4), p.382-388
Description: To study the efficacy of 0.2‐Hz repetitive transcranial magnetic stimulation (rTMS) on Parkinson's disease (PD), 85 patients with PD were enrolled into three groups: 1) motor cortical, 2) occipital, and 3) sham stimulation. A round coil was centered over the vertex in motor cortical stimulation, and over the inion in occipital stimulation. In one session, 100 stimuli of 0.2‐Hz rTMS at an intensity of 1.1 times active motor threshold (AMT) were given. In sham stimulation, electric currents were given with electrodes fixed on the head to mimic the sensation in real stimulation. Each session was carried out once a week for the first 8 weeks. The Unified Parkinson Disease Rating Scale (UPDRS), Hamilton Rating Scale for Depression (HRSD) and subjective score (visual analogue scale) were assessed. There were no significant differences in clinical features among the three groups. Total and motor score of UPDRS were improved to the same extent by rTMS over Cz, inion, and sham stimulation. HRSD was improved by rTMS over Cz and sham stimulation in the same manner. Subjective score was not significantly improved by any methods of stimulation. 0.2‐Hz rTMS at an intensity of 1.1 × AMT has only a placebo effect on PD. Our realistic sham stimulation maneuver must produce powerful placebo effects as a real stimulation. © 2002 Movement Disorder Society
Publisher: New York: Wiley Subscription Services, Inc., A Wiley Company
Language: English
Identifier: ISSN: 0885-3185
EISSN: 1531-8257
DOI: 10.1002/mds.10370
PMID: 12671943
Source: MEDLINE
Alma/SFX Local Collection

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0.2-Hz repetitive transcranial magnetic stimulation has no add-on effects as compared to a realistic sham stimulation in Parkinson's disease

Copyright © 2003 Movement Disorders Society ;2003 INIST-CNRS ;Copyright 2002 Movement Disorder Society ;ISSN: 0885-3185 ;EISSN: 1531-8257 ;DOI: 10.1002/mds.10370 ;PMID: 12671943

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