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IGATA3/I as a Blood-Based RNA Biomarker for Idiopathic Parkinson’s Disease

International journal of molecular sciences, 2023-06, Vol.24 (12) [Peer Reviewed Journal]

COPYRIGHT 2023 MDPI AG ;ISSN: 1422-0067 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms241210040

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  • Title:
    IGATA3/I as a Blood-Based RNA Biomarker for Idiopathic Parkinson’s Disease
  • Author: Acharya, Shubhra ; Lumley, Andrew I ; Zhang, Lu ; Vausort, Mélanie ; Devaux, Yvan
  • Subjects: Analysis ; Diagnosis ; Medical research ; Medicine, Experimental ; RNA ; Sleep disorders
  • Is Part Of: International journal of molecular sciences, 2023-06, Vol.24 (12)
  • Description: Finding novel biomarkers for Parkinson’s disease (PD) is crucial for early disease diagnosis, severity assessment and identifying novel disease-modifying drug targets. Our study aimed at investigating the GATA3 mRNA levels in whole blood samples of idiopathic PD (iPD) patients with different disease severities as a biomarker for iPD. The present study is a cross-sectional, case-control study, with samples obtained from the Luxembourg Parkinson’s cohort (LuxPARK). iPD (N = 319) patients, along with age-matched controls without PD (non-PD; N = 319) were included in this study. Blood GATA3 mRNA expression was measured using quantitative reverse transcription PCR (RT-qPCR) assays. The capacity of GATA3 expression levels to establish the diagnosis of iPD (primary end-point) and assess disease severity (secondary end-point) was determined. The blood levels of GATA3 were significantly lower in iPD patients, compared to non-PD controls (p ≤ 0.001). Logistic regression models showed a significant association of GATA3 expression with iPD diagnosis after adjustment for the confounders (p = 0.005). Moreover, the addition of GATA3 expression to a baseline clinical model improved its iPD diagnosis capacity (p = 0.005). There was a significant association of GATA3 expression levels with the overall disease severity (p = 0.002), non-motor experiences of daily living (nm-EDL; p = 0.003) and sleep disturbances (p = 0.01). Our results suggest that GATA3 expression measured in blood may serve as a novel biomarker and may help in the diagnosis of iPD and assessment of disease severity.
  • Publisher: MDPI AG
  • Language: English
  • Identifier: ISSN: 1422-0067
    EISSN: 1422-0067
    DOI: 10.3390/ijms241210040
  • Source: PubMed Central
    Directory of Open Access Journals
    ProQuest Central
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