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Balancing the fat: lipid droplets and human disease

EMBO molecular medicine, 2013-07, Vol.5 (7), p.973-983 [Peer Reviewed Journal]

Copyright © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO ;2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO. ;2013. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO 2013 ;ISSN: 1757-4676 ;EISSN: 1757-4684 ;DOI: 10.1002/emmm.201100671 ;PMID: 23740690

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Title:
Balancing the fat: lipid droplets and human disease
Author: Krahmer, Natalie ; Farese, Robert V. ; Walther, Tobias C.
Subjects: Adipocytes ; Animals ; Apoptosis ; atherosclerosis ; Body fat ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - metabolism ; Cholesterol ; Congenital diseases ; Cytoplasmic Granules - metabolism ; Cytoplasmic Granules - pathology ; Defects ; Disease ; Energy ; Enzymes ; Fatty acids ; Fatty Liver - complications ; Fatty Liver - metabolism ; Genes ; Humans ; Insulin resistance ; Kinases ; lipid droplet ; Lipid Metabolism ; Lipids ; lipodystrophy ; metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - metabolism ; Metabolic Syndrome - pathology ; Metabolism ; Morphology ; Obesity - complications ; Obesity - metabolism ; Organelles ; Proteins ; Review ; Sterols ; triglyceride storage
Is Part Of: EMBO molecular medicine, 2013-07, Vol.5 (7), p.973-983
Description: Lipid droplets (LDs) are dynamic, cytosolic lipid‐storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat storage lead to many different human diseases. Recent insights into LD biology and LD protein functions shed new light on mechanisms underlying those metabolic pathologies. These findings will likely provide opportunities for treatment of diseases associated with too much or too little fat. Too many or too few lipid droplets during excess or deficient fat storage lead to many different human diseases. Recent insights into lipid droplet biology and functions shed new light on mechanisms underlying those metabolic pathologies.
Publisher: England: John Wiley & Sons, Inc
Language: English
Identifier: ISSN: 1757-4676
EISSN: 1757-4684
DOI: 10.1002/emmm.201100671
PMID: 23740690
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Balancing the fat: lipid droplets and human disease

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