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Calcium Signaling and Cardiac Arrhythmias

Circulation research, 2017-06, Vol.120 (12), p.1969-1993 [Peer Reviewed Journal]

2017 American Heart Association, Inc. ;Copyright Lippincott Williams & Wilkins Ovid Technologies Jun 9, 2017 ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.117.310083 ;PMID: 28596175

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Title:
Calcium Signaling and Cardiac Arrhythmias
Author: Landstrom, Andrew P ; Dobrev, Dobromir ; Wehrens, Xander H.T
Subjects: Animals ; Arrhythmia ; Arrhythmias, Cardiac - metabolism ; Arrhythmias, Cardiac - physiopathology ; Calcium channels ; Calcium Signaling - physiology ; Calcium signalling ; Cardiac arrhythmia ; Cardiomyopathy ; Contraction ; Coronary artery disease ; Electrocardiography ; Heart Conduction System - metabolism ; Heart Conduction System - physiopathology ; Heart diseases ; Humans ; Long QT syndrome ; Molecular modelling ; Mutation ; Myocytes, Cardiac - metabolism ; Ryanodine Receptor Calcium Release Channel - metabolism ; Sarcoplasmic Reticulum - metabolism ; Tachycardia ; Therapeutic applications ; Ventricle
Is Part Of: Circulation research, 2017-06, Vol.120 (12), p.1969-1993
Description: There has been a significant progress in our understanding of the molecular mechanisms by which calcium (Ca) ions mediate various types of cardiac arrhythmias. A growing list of inherited gene defects can cause potentially lethal cardiac arrhythmia syndromes, including catecholaminergic polymorphic ventricular tachycardia, congenital long QT syndrome, and hypertrophic cardiomyopathy. In addition, acquired deficits of multiple Ca-handling proteins can contribute to the pathogenesis of arrhythmias in patients with various types of heart disease. In this review article, we will first review the key role of Ca in normal cardiac function—in particular, excitation–contraction coupling and normal electric rhythms. The functional involvement of Ca in distinct arrhythmia mechanisms will be discussed, followed by various inherited arrhythmia syndromes caused by mutations in Ca-handling proteins. Finally, we will discuss how changes in the expression of regulation of Ca channels and transporters can cause acquired arrhythmias, and how these mechanisms might be targeted for therapeutic purposes.
Publisher: United States: American Heart Association, Inc
Language: English
Identifier: ISSN: 0009-7330
EISSN: 1524-4571
DOI: 10.1161/CIRCRESAHA.117.310083
PMID: 28596175
Source: GFMER Free Medical Journals
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Calcium Signaling and Cardiac Arrhythmias

2017 American Heart Association, Inc. ;Copyright Lippincott Williams & Wilkins Ovid Technologies Jun 9, 2017 ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.117.310083 ;PMID: 28596175

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