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Real-time measurement of small molecules directly in awake, ambulatory animals

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (4), p.645-650 [Peer Reviewed Journal]

Volumes 1–89 and 106–114, copyright as a collective work only; author(s) retains copyright to individual articles ;Copyright National Academy of Sciences Jan 24, 2017 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1613458114 ;PMID: 28069939

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Title:
Real-time measurement of small molecules directly in awake, ambulatory animals
Author: Arroyo-Currás, Netzahualcóyotl ; Somerson, Jacob ; Vieira, Philip A. ; Ploense, Kyle L. ; Kippin, Tod E. ; Plaxco, Kevin W.
Subjects: Animals ; Aptamers, Nucleotide - metabolism ; Biological Sciences ; Biomarkers ; Biosensing Techniques - methods ; Cattle ; Humans ; Limit of Detection ; Male ; Medical treatment ; Metabolites ; Pharmaceutical Preparations - blood ; Pharmaceutical Preparations - metabolism ; Physical Sciences ; Rats ; Rats, Sprague-Dawley ; Sensors ; Small Molecule Libraries - metabolism
Is Part Of: Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (4), p.645-650
Description: The development of a technology capable of tracking the levels of drugs, metabolites, and biomarkers in the body continuously and in real time would advance our understanding of health and our ability to detect and treat disease. It would, for example, enable therapies guided by high-resolution, patient-specific pharmacokinetics (including feedback-controlled drug delivery), opening new dimensions in personalized medicine. In response, we demonstrate here the ability of electrochemical aptamer-based (E-AB) sensors to support continuous, real-time, multihour measurements when emplaced directly in the circulatory systems of living animals. Specifically, we have used E-AB sensors to perform the multihour, real-time measurement of four drugs in the bloodstream of even awake, ambulatory rats, achieving precise molecular measurements at clinically relevant detection limits and high (3 s) temporal resolution, attributes suggesting that the approach could provide an important window into the study of physiology and pharmacokinetics.
Publisher: United States: National Academy of Sciences
Language: English
Identifier: ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.1613458114
PMID: 28069939
Source: Open Access: PubMed Central
Geneva Foundation Free Medical Journals at publisher websites
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Real-time measurement of small molecules directly in awake, ambulatory animals

Volumes 1–89 and 106–114, copyright as a collective work only; author(s) retains copyright to individual articles ;Copyright National Academy of Sciences Jan 24, 2017 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1613458114 ;PMID: 28069939

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