Language:

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

Immunity (Cambridge, Mass.), 2020-06, Vol.52 (6), p.1039-1056.e9 [Peer Reviewed Journal]

2020 Elsevier Inc. ;Copyright © 2020 Elsevier Inc. All rights reserved. ;2020. Elsevier Inc. ;2020 Elsevier Inc. 2020 Elsevier Inc. ;ISSN: 1074-7613 ;EISSN: 1097-4180 ;DOI: 10.1016/j.immuni.2020.04.005 ;PMID: 32392463

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection
Author: Bosteels, Cedric ; Neyt, Katrijn ; Vanheerswynghels, Manon ; van Helden, Mary J. ; Sichien, Dorine ; Debeuf, Nincy ; De Prijck, Sofie ; Bosteels, Victor ; Vandamme, Niels ; Martens, Liesbet ; Saeys, Yvan ; Louagie, Els ; Lesage, Manon ; Williams, David L. ; Tang, Shiau-Choot ; Mayer, Johannes U. ; Ronchese, Franca ; Scott, Charlotte L. ; Hammad, Hamida ; Guilliams, Martin ; Lambrecht, Bart N.
Subjects: Antigen Presentation ; Antigen-presenting cells ; Antigens ; Biomarkers ; CD4 antigen ; CD64 ; CD8 antigen ; Cell culture ; Cell Plasticity - immunology ; Chemokines ; convalescent serum ; dendritic cell ; Dendritic cells ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Disease Susceptibility ; Fc receptor ; Fc receptors ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; Immunity ; Immunophenotyping ; inf-cDC2 ; Infections ; Inflammation ; Interferon ; Interferon regulatory factor 4 ; Interferon Type I - metabolism ; IRF8 ; Kinases ; Lungs ; Lymphocytes ; Lymphocytes T ; Macrophages ; Macrophages - immunology ; Macrophages - metabolism ; monocyte ; Monocytes ; Monocytes - immunology ; Monocytes - metabolism ; Organ Specificity - immunology ; Population ; Receptors ; Receptors, Fc - metabolism ; Respirovirus Infections - etiology ; Respirovirus Infections - metabolism ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - metabolism ; Toll-like receptors ; transcription factor ; Transcription Factors ; type 1 interferon ; Viral infections ; virus ; Virus Diseases - genetics ; Virus Diseases - immunology ; Virus Diseases - metabolism ; Virus Diseases - virology ; Viruses
Is Part Of: Immunity (Cambridge, Mass.), 2020-06, Vol.52 (6), p.1039-1056.e9
Description: The phenotypic and functional dichotomy between IRF8+ type 1 and IRF4+ type 2 conventional dendritic cells (cDC1s and cDC2s, respectively) is well accepted; it is unknown how robust this dichotomy is under inflammatory conditions, when additionally monocyte-derived cells (MCs) become competent antigen-presenting cells (APCs). Using single-cell technologies in models of respiratory viral infection, we found that lung cDC2s acquired expression of the Fc receptor CD64 shared with MCs and of IRF8 shared with cDC1s. These inflammatory cDC2s (inf-cDC2s) were superior in inducing CD4+ T helper (Th) cell polarization while simultaneously presenting antigen to CD8+ T cells. When carefully separated from inf-cDC2s, MCs lacked APC function. Inf-cDC2s matured in response to cell-intrinsic Toll-like receptor and type 1 interferon receptor signaling, upregulated an IRF8-dependent maturation module, and acquired antigens via convalescent serum and Fc receptors. Because hybrid inf-cDC2s are easily confused with monocyte-derived cells, their existence could explain why APC functions have been attributed to MCs. [Display omitted] •Type I interferon drives differentiation of inf-cDC2s that closely resemble MCs•Inf-cDC2s prime CD4+ and CD8+ T cells, whereas MCs lack APC function•Inf-cDC2s internalize antibody-complexed antigen via Fc receptors•IRF8 controls maturation gene module in inf-cDC2s The dichotomy between type 1 and 2 conventional DCs under steady-state conditions is well defined. Bosteels et al. demonstrate that, upon inflammation, cDC2s acquire a hybrid inf-cDC2 phenotype, sharing phenotype, gene expression, and function with cDC1s and monocyte-derived cells, to optimally boost CD4 and CD8 immunity via Fc receptors.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 1074-7613
EISSN: 1097-4180
DOI: 10.1016/j.immuni.2020.04.005
PMID: 32392463
Source: MEDLINE
Open Access: Cell Press Free Archives

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

2020 Elsevier Inc. ;Copyright © 2020 Elsevier Inc. All rights reserved. ;2020. Elsevier Inc. ;2020 Elsevier Inc. 2020 Elsevier Inc. ;ISSN: 1074-7613 ;EISSN: 1097-4180 ;DOI: 10.1016/j.immuni.2020.04.005 ;PMID: 32392463

Searching Remote Databases, Please Wait