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Long-term cardiovascular outcomes of COVID-19

Nature medicine, 2022-03, Vol.28 (3), p.583-590 [Peer Reviewed Journal]

2022. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply. ;This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2022 ;ISSN: 1078-8956 ;EISSN: 1546-170X ;DOI: 10.1038/s41591-022-01689-3 ;PMID: 35132265

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Title:
Long-term cardiovascular outcomes of COVID-19
Author: Xie, Yan ; Xu, Evan ; Bowe, Benjamin ; Al-Aly, Ziyad
Subjects: Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cerebrovascular diseases ; Cohort Studies ; Complications ; Congestive heart failure ; Coronary artery disease ; Coronaviruses ; COVID-19 ; COVID-19 - complications ; COVID-19 - epidemiology ; Disorders ; Health care ; Health risks ; Heart diseases ; Heart Failure - epidemiology ; Hospitalization ; Humans ; Infections ; Ischemia ; Myocarditis ; Pericarditis ; Risk ; Thromboembolism ; Viral diseases
Is Part Of: Nature medicine, 2022-03, Vol.28 (3), p.583-590
Description: The cardiovascular complications of acute coronavirus disease 2019 (COVID-19) are well described, but the post-acute cardiovascular manifestations of COVID-19 have not yet been comprehensively characterized. Here we used national healthcare databases from the US Department of Veterans Affairs to build a cohort of 153,760 individuals with COVID-19, as well as two sets of control cohorts with 5,637,647 (contemporary controls) and 5,859,411 (historical controls) individuals, to estimate risks and 1-year burdens of a set of pre-specified incident cardiovascular outcomes. We show that, beyond the first 30 d after infection, individuals with COVID-19 are at increased risk of incident cardiovascular disease spanning several categories, including cerebrovascular disorders, dysrhythmias, ischemic and non-ischemic heart disease, pericarditis, myocarditis, heart failure and thromboembolic disease. These risks and burdens were evident even among individuals who were not hospitalized during the acute phase of the infection and increased in a graded fashion according to the care setting during the acute phase (non-hospitalized, hospitalized and admitted to intensive care). Our results provide evidence that the risk and 1-year burden of cardiovascular disease in survivors of acute COVID-19 are substantial. Care pathways of those surviving the acute episode of COVID-19 should include attention to cardiovascular health and disease.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1078-8956
EISSN: 1546-170X
DOI: 10.1038/s41591-022-01689-3
PMID: 35132265
Source: MEDLINE
ProQuest Central

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Long-term cardiovascular outcomes of COVID-19

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