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COMPUESTOS HETEROAROMÁTICOS Y SU USO COMO LIGANDOS D1 DE DOPAMINA
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Title:
COMPUESTOS HETEROAROMÁTICOS Y SU USO COMO LIGANDOS D1 DE DOPAMINA
Author:
11. ROGERS, BRUCE NELSEN
;
7. HENDERSON, JACLYN LOUISE
;
2. DAVOREN, JENNIFER ELIZABETH
;
4. EFREMOV, IVAN VIKTOROVICH
;
1. BRODNEY, MICHAEL AARON
;
6. GREEN, MICHAEL ERIC
;
8. LEE, CHEWAH
;
10. O'NEIL, STEVEN VICTOR
;
9. MENTE, SCOT RICHARD
;
3. DOUNAY, AMY BETH
;
5. GRAY, DAVID LAWRENCE FIRMAN
Subjects:
CHEMISTRY
;
HETEROCYCLIC COMPOUNDS
;
HUMAN NECESSITIES
;
HYGIENE
;
MEDICAL OR VETERINARY SCIENCE
;
METALLURGY
;
ORGANIC CHEMISTRY
;
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
;
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Description:
LA PRESENTE INVENCIÓN PROPORCIONA, EN PARTE, LOS COMPUESTOS DE LA FÓRMULA I Y SALES FARMACÉUTICAMENTE ACEPTABLES DE LO MISMOS; PROCESOS PARA LA PREPARACIÓN DE; INTERMEDIARIOS UTILIZADOS EN LA PREPARACIÓN DE; Y COMPOSICIONES QUE CONTIENEN LOS COMPUESTOS O SALES, Y SU USOS PARA TRATAR LOS TRASTORNOS MEDIADOS POR D1 (O ASOCIADOS CON D1) QUE INCLUYEN, POR EJEMPLO, ESQUIZOFRENIA (POR EJEMPLO, SUS SÍNTOMAS COGNITIVOS Y NEGATIVOS), DISCAPACIDAD COGNITIVA (POR EJEMPLO, DISCAPACIDAD COGNITIVA ASOCIADA CON ESQUIZOFRENIA, AD, PD, O TERAPIA DE FARMACOTERAPIA), ADHD, IMPULSIVIDAD, JUEGO COMPULSIVO, COMER EN EXCESO, TRASTORNO DEL ESPECTRO DE AUTISMO, MCI, DECLIVE COGNITIVO RELACIONADO CON LA EDAD, DEMENCIA, RLS, ENFERMEDAD DE PARKINSON, COREA DE HUNTINGTON, ANSIEDAD, DEPRESIÓN, MDD, TRD, TRASTORNO BIPOLAR, APATÍA CRÓNICA, ANHEDONIA, FÁTIGA CRÓNICA, TRASTORNO POR ESTRÉS POST-TRAUMÁTICO, TRASTORNO AFECTIVO ESTACIONAL, TRASTORNO DE ANSIEDAD SOCIAL, DEPRESIÓN POST-PARTO, SÍNDROME DE SEROTONINA, DEPENDENCIA DE ABUSO DE SUSTANCIAS Y FÁRMACOS, RECAÍDA POR ABUSO DE FÁRMACOS, SÍNDROME DE TOURETTE, DISQUINESIA TARDÍA, SOMNOLENCIA, SOMNOLENCIA DIURNA EXCESIVA, CAQUEXIA, FALTA DE ATENCIÓN, DISFUNCIÓN SEXUAL, MIGRAÑA, SLE, HIPERGLICEMIA, ATEROSCLEROSIS, DISLIPIDEMIA, OBESIDAD, DIABETES, SEPSIS, NECROSIS TUBULAR POST-ISQUÉMICA, FALLA RENAL, HIPONATREMIA, EDEMA RESISTENTE, NARCOLEPSIA, HIPERTENSIÓN, FALLA CARDIACA COGESTIVA, HIPOTONIA OCULAR POSTOPERATIVA, TRASTORNOS DEL SUEÑO, Y DOLOR. The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), age-related cognitive decline, dementia, and Parkinson's disease.
Creation Date:
2017
Language:
Spanish
Source:
esp@cenet
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