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Redefining critical illness
Springer Nature America, Inc. 2022. The final publication is available at Springer via https://doi.org/10.1038/s41591-022-01843-x ;ISSN: 1078-8956 ;EISSN: 1546-170X ;DOI: 10.1038/s41591-022-01843-x
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Title:
Redefining critical illness
Author:
Maslove, DM
;
Tang, B
;
Shankar-Hari, M
;
Lawler, PR
;
Angus, DC
;
Baillie, JK
;
Baron, RM
;
Bauer, M
;
Buchman, TG
;
Calfee, CS
;
Dos Santos, CC
;
Giamarellos-Bourboulis, EJ
;
Gordon, AC
;
Kellum, JA
;
Knight, JC
;
Leligdowicz, A
;
McAuley, DF
;
McLean, AS
;
Menon, DK
;
Meyer, NJ
;
Moldawer, LL
;
Reddy, K
;
Reilly, JP
;
Russell, JA
;
Sevransky, JE
;
Seymour, CW
;
Shapiro, NI
;
Singer, M
;
Summers, C
;
Sweeney, TE
;
Thompson, BT
;
Van der Poll, T
;
Venkatesh, B
;
Walley, KR
;
Walsh, TS
;
Ware, LB
;
Wong, HR
;
Zador, ZE
;
Marshall, JC
Subjects:
11 Medical and Health Sciences
;
Immunology
Description:
Research and practice in critical care medicine have long been defined by syndromes, which, despite being clinically recognizable entities, are, in fact, loose amalgams of heterogeneous states that may respond differently to therapy. Mounting translational evidence—supported by research on respiratory failure due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection—suggests that the current syndrome-based framework of critical illness should be reconsidered. Here we discuss recent findings from basic science and clinical research in critical care and explore how these might inform a new conceptual model of critical illness. De-emphasizing syndromes, we focus on the underlying biological changes that underpin critical illness states and that may be amenable to treatment. We hypothesize that such an approach will accelerate critical care research, leading to a richer understanding of the pathobiology of critical illness and of the key determinants of patient outcomes. This, in turn, will support the design of more effective clinical trials and inform a more precise and more effective practice at the bedside.
Publisher:
Springer Science and Business Media LLC
Creation Date:
2022-04
Language:
English
Identifier:
ISSN: 1078-8956
EISSN: 1546-170X
DOI: 10.1038/s41591-022-01843-x
Source:
AUTh Library subscriptions: ProQuest Central
Spiral
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