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The impact of triglyceride-glucose index on incident cardiovascular events during 16 years of follow-up: Tehran Lipid and Glucose Study

Cardiovascular diabetology, 2020-09, Vol.19 (1), p.155-155, Article 155 [Peer Reviewed Journal]

2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2020 ;ISSN: 1475-2840 ;EISSN: 1475-2840 ;DOI: 10.1186/s12933-020-01121-5 ;PMID: 32993633

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Title:
The impact of triglyceride-glucose index on incident cardiovascular events during 16 years of follow-up: Tehran Lipid and Glucose Study
Author: Barzegar, Niloofar ; Tohidi, Maryam ; Hasheminia, Mitra ; Azizi, Fereidoun ; Hadaegh, Farzad
Subjects: Adult ; Age ; Age Factors ; Angina pectoris ; Biomarkers ; Biomarkers - blood ; Blood Glucose - analysis ; Blood pressure ; Body mass index ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cholesterol ; Coronary artery disease ; Coronary heart disease ; Diabetes mellitus (non-insulin dependent) ; Education ; Electrocardiography ; Family medical history ; Fasting ; Female ; Gender ; Glucose ; Heart diseases ; Humans ; Hypertension ; Incidence ; Iran - epidemiology ; Laboratories ; Lipids ; Male ; Middle Aged ; Mortality ; Multivariate analysis ; Original Investigation ; Physical activity ; Population ; Prognosis ; Prospective Studies ; Questionnaires ; Risk Assessment ; Risk Factors ; Smoking ; Standard deviation ; Triglycerides - blood ; TyG-index
Is Part Of: Cardiovascular diabetology, 2020-09, Vol.19 (1), p.155-155, Article 155
Description: To investigate whether the Triglyceride-Glucose index (TyG-index) is associated with increased risk of cardiovascular diseases (CVD)/coronary heart disease (CHD). A total of 7521 Iranians aged ≥ 30 years (male = 3367) were included in the study. Multivariate Cox regression analyses (adjusted for age, gender, waist circumference, body mass index, educational level, smoking status, physical activity, family history of CVD, type 2 diabetes, hypertension, low and high density lipoprotein cholesterol, and lipid lowering drugs) were used to assess the risk of incident CVD/CHD across quintiles and for 1-standard deviation (SD) increase in the TyG-index. The cut off point for TyG-index was assessed by the minimum value of [Formula: see text]. We also examined the added value of the TyG-index in addition to the Framingham risk score when predicting CVD. During follow-up, 1084 cases of CVD (male = 634) were recorded. We found a significant trend of TyG-index for incident CVD/CHD in multivariate analysis (both Ps for tend ≤ 0.002). Moreover, a 1-SD increase in TyG-index was associated with significant risk of CVD/CHD in multivariate analysis [1.16 (1.07-1.25) and 1.19 (1.10-1.29), respectively]. The cut-off value of TyG-index for incident CVD was 9.03 (59.2% sensitivity and 63.2% specificity); the corresponding value of TyG-index for incident CHD was 9.03 (60.0% sensitivity and 62.8% specificity), respectively. Although no interaction was found between gender and TyG-index for CVD/CHD in multivariate analysis (both Ps for interaction > 0.085), the significant trend of TyG-index was observed only among females for incident CVD (P = 0.035). A significant interaction was found between age groups (i.e. ≥ 60 vs < 60 years) and TyG-index for CVD outcomes in the multivariate model (P-value for interaction = 0.046). Accordingly, a significant association between the TyG-index and outcomes was found only among the younger age group. Among the population aged < 60 the addition of TyG-index to the Framingham risk score (FRS) did not show improvement in the predictive ability of the FRS, using integrated discrimination improvement. The TyG-index is significantly associated with increased risk of CVD/CHD incidence; this issue was more prominent among the younger population. However, adding TyG-index to FRS does not provide better risk prediction for CVD.
Publisher: England: BioMed Central
Language: English
Identifier: ISSN: 1475-2840
EISSN: 1475-2840
DOI: 10.1186/s12933-020-01121-5
PMID: 32993633
Source: SpringerOpen
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

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The impact of triglyceride-glucose index on incident cardiovascular events during 16 years of follow-up: Tehran Lipid and Glucose Study

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