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Novel Therapeutic Method for Unresectable Pancreatic Cancer-The Impact of the Long-Term Research in Therapeutic Effect of High-Intensity Focused Ultrasound (HIFU) Therapy

Current oncology (Toronto), 2021-11, Vol.28 (6), p.4845-4861 [Peer Reviewed Journal]

2021 by the authors. 2021 ;ISSN: 1718-7729 ;ISSN: 1198-0052 ;EISSN: 1718-7729 ;DOI: 10.3390/curroncol28060409 ;PMID: 34898585

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Title:
Novel Therapeutic Method for Unresectable Pancreatic Cancer-The Impact of the Long-Term Research in Therapeutic Effect of High-Intensity Focused Ultrasound (HIFU) Therapy
Author: Sofuni, Atsushi ; Asai, Yasutsugu ; Tsuchiya, Takayoshi ; Ishii, Kentaro ; Tanaka, Reina ; Tonozuka, Ryosuke ; Honjo, Mitsuyoshi ; Mukai, Shuntaro ; Nagai, Kazumasa ; Yamamoto, Kenjiro ; Matsunami, Yukitoshi ; Kurosawa, Takashi ; Kojima, Hiroyuki ; Homma, Toshihiro ; Minami, Hirohito ; Nakatsubo, Ryosuke ; Hirakawa, Noriyuki ; Miyazawa, Hideaki ; Nagakawa, Yuichi ; Tsuchida, Akihiko ; Itoi, Takao
Subjects: combination therapy ; Combined Modality Therapy ; Extracorporeal Shockwave Therapy ; high-intensity focused ultrasound (HIFU) ; High-Intensity Focused Ultrasound Ablation - adverse effects ; High-Intensity Focused Ultrasound Ablation - methods ; Humans ; pancreatic cancer ; Pancreatic Neoplasms - pathology ; tumor ablation
Is Part Of: Current oncology (Toronto), 2021-11, Vol.28 (6), p.4845-4861
Description: High-intensity focused ultrasound (HIFU) is a novel advanced therapy for unresectable pancreatic cancer (PC). HIFU therapy with chemotherapy is being promoted as a novel method to control local advancement by tumor ablation. We evaluated the therapeutic effects of HIFU therapy in locally advanced and metastatic PC. PC patients were treated with HIFU as an optional local therapy and systemic chemotherapy. The FEP-BY02 (Yuande Bio-Medical Engineering) HIFU device was used under ultrasound guidance. Of 176 PC patients, 89 cases were Stage III and 87 were Stage IV. The rate of complete tumor ablation was 90.3%, while that of symptom relief was 66.7%. The effectiveness on the primary lesions were as follows: complete response (CR): n = 0, partial response (PR): n = 21, stable disease (SD): n = 106, and progressive disease (PD): n = 49; the primary disease control rate was 72.2%. Eight patients underwent surgery. The median survival time (MST) after diagnosis for HIFU with chemotherapy compared to chemotherapy alone (100 patients in our hospital) was 648 vs. 288 days ( < 0.001). Compared with chemotherapy alone, the combination of HIFU therapy and chemotherapy demonstrated significant prolongation of prognosis. This study suggests that HIFU therapy has the potential to be a novel combination therapy for unresectable PC.
Publisher: Switzerland: MDPI
Language: English
Identifier: ISSN: 1718-7729
ISSN: 1198-0052
EISSN: 1718-7729
DOI: 10.3390/curroncol28060409
PMID: 34898585
Source: MEDLINE
PubMed Central
Alma/SFX Local Collection
DOAJ Directory of Open Access Journals

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Novel Therapeutic Method for Unresectable Pancreatic Cancer-The Impact of the Long-Term Research in Therapeutic Effect of High-Intensity Focused Ultrasound (HIFU) Therapy

2021 by the authors. 2021 ;ISSN: 1718-7729 ;ISSN: 1198-0052 ;EISSN: 1718-7729 ;DOI: 10.3390/curroncol28060409 ;PMID: 34898585

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