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Incidental Findings Suggestive of COVID-19 in Asymptomatic Patients Undergoing Nuclear Medicine Procedures in a High-Prevalence Region

Journal of Nuclear Medicine, 2020-05, Vol.61 (5), p.632-636 [Peer Reviewed Journal]

2020 by the Society of Nuclear Medicine and Molecular Imaging. ;Copyright Society of Nuclear Medicine May 1, 2020 ;ISSN: 0161-5505 ;EISSN: 1535-5667 ;EISSN: 2159-662X ;DOI: 10.2967/jnumed.120.246256 ;PMID: 32238429

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Title:
Incidental Findings Suggestive of COVID-19 in Asymptomatic Patients Undergoing Nuclear Medicine Procedures in a High-Prevalence Region
Author: Albano, Domenico ; Bertagna, Francesco ; Bertoli, Mattia ; Bosio, Giovanni ; Lucchini, Silvia ; Motta, Federica ; Panarotto, Maria Beatrice ; Peli, Alessia ; Camoni, Luca ; Bengel, Frank M ; Giubbini, Raffaele
Subjects: Aged ; Asymptomatic ; Asymptomatic Diseases ; Avidity ; Betacoronavirus ; Computed tomography ; Coronaviridae ; Coronavirus Infections - complications ; Coronavirus Infections - diagnosis ; Coronaviruses ; COVID-19 ; Female ; Fluorine isotopes ; Fluorodeoxyglucose F18 ; Humans ; Incidental Findings ; Infection Control ; Infections ; Iodine 131 ; Iodine radioisotopes ; Lung Diseases, Interstitial - diagnostic imaging ; Lung Diseases, Interstitial - etiology ; Male ; Medical imaging ; Medicine ; Membrane Glycoproteins ; Middle Aged ; Neoplasms - diagnostic imaging ; Nuclear medicine ; Nuclear Medicine - trends ; Pandemics ; Pneumonia ; Pneumonia, Viral - complications ; Pneumonia, Viral - diagnosis ; Polymerase chain reaction ; Positron emission ; Positron emission tomography ; Positron Emission Tomography Computed Tomography ; Prevalence ; Respiratory diseases ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Single photon emission computed tomography ; Thyroid ; Thyroid carcinoma ; Tomography ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed ; Viral diseases
Is Part Of: Journal of Nuclear Medicine, 2020-05, Vol.61 (5), p.632-636
Description: Infection with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may remain asymptomatic, leading to under-recognition of the related disease, coronavirus disease, 2019 (COVID-19), and to incidental findings in nuclear imaging procedures performed for standard clinical indications. Here, we report about our local experience in a region with high COVID-19 prevalence and dynamically increasing infection rates. Within the 8-d period of March 16-24, 2020, hybrid imaging studies of asymptomatic patients who underwent F-FDG PET/CT or I SPECT/CT for standard oncologic indications at our institution in Brescia, Italy, were analyzed for findings suggestive of COVID-19. The presence, radiologic features, and metabolic activity of interstitial pneumonia were identified, correlated with the subsequent short-term clinical course, and described in a case series. Six of 65 patients (9%) who underwent PET/CT for various malignancies showed unexpected signs of interstitial pneumonia on CT and elevated regional F-FDG avidity. Additionally, 1 of 12 patients who received radioiodine for differentiated thyroid carcinoma also showed interstitial pneumonia on SPECT/CT. Five of 7 patients had subsequent proof of COVID-19 by reverse-transcriptase polymerase chain reaction. The remaining 2 patients were not tested immediately but underwent quarantine and careful monitoring. Incidental findings suggestive of COVID-19 may not be infrequent in hybrid imaging of asymptomatic patients in regions with an expansive spread of SARS-CoV-2. Nuclear medicine services should prepare accordingly.
Publisher: United States: Society of Nuclear Medicine
Language: English
Identifier: ISSN: 0161-5505
EISSN: 1535-5667
EISSN: 2159-662X
DOI: 10.2967/jnumed.120.246256
PMID: 32238429
Source: MEDLINE
Alma/SFX Local Collection

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Incidental Findings Suggestive of COVID-19 in Asymptomatic Patients Undergoing Nuclear Medicine Procedures in a High-Prevalence Region

2020 by the Society of Nuclear Medicine and Molecular Imaging. ;Copyright Society of Nuclear Medicine May 1, 2020 ;ISSN: 0161-5505 ;EISSN: 1535-5667 ;EISSN: 2159-662X ;DOI: 10.2967/jnumed.120.246256 ;PMID: 32238429

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